Prenyltransferase
Prenyltransferases are a class of enzymes that transfer allylic prenyl groups to acceptor molecules. Prenyl transferases commonly refer to prenyl diphosphate synthases.
Prenyltransferases are commonly divided into two classes, cis and trans, depending upon the stereochemistry of the resulting products. Examples of trans-prenyltranferases include dimethylallyltranstransferase, and geranylgeranyl pyrophosphate synthase. Cis-prenyltransferases include dehydrodolichol diphosphate synthase.
The beta subunit of the farnesyltransferases is responsible for peptide binding. Squalene-hopene cyclase is a bacterial enzyme that catalyzes the cyclization of squalene into hopene, a key step in hopanoid metabolism. Lanosterol synthase catalyzes the cyclization of -2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi. Cycloartenol synthase is a plant enzyme that catalyzes the cyclization of -2,3-epoxysqualene to cycloartenol.Human proteins containing this domain
; LSS; PGGT1B; RABGGTB
