Botelho made her professional debut in 2013, getting knockout wins over Thais Raphaela and Ingrid Schwartz in Favela Kombat and KTAF respectively. In 2014, she fought for the vacant flyweight title in the promotion Bitetti Combat. She lost the bout via Unanimous Decision to fellow Brazilian Mixed Martial ArtistViviane Pereira. She later signed to the Xtreme Fighting Championships as a Flyweight.
Xtreme Fighting Championships
In 2014, Botelho joined XFC's second women's flyweight tournament. She made her promotional debut in September 2014 at XFCi 6 against Karina Rodriguez, winning the fight by TKO. The win propelled her to the tournament's semifinal round. Botelho was then slated to fight Taila Santos at XFCi 8 in December 2014. However, Santos failed to make weight, leading to the cancellation of the bout. Botelho, in turn, was advanced to the tournament's final round. In March 2015, Botelho fought once more under the XFC banner, this time taking on Antonia Silvaneide in the Women's Flyweight Tournament Final at XFCi 9. She won the fight by TKO in the first round, becoming the second winner in the history of the tournament. After the win, she was honored with a parade in her hometown. Later that year, Botelho faced Argentine fighter Silvana Gómez Juárez, this time for the vacant XFC Women's Flyweight belt at XFCi 11. Despite being dropped and nearly submitted in the early rounds, Botelho went on to win the fight after a doctor stoppage between rounds. Botelho became the promotion's Women's Flyweight Champion. After her success in XFC, Botelho vacated the title and was signed to the Ultimate Fighting Championship in 2016.
Ultimate Fighting Championship
Botelho joined the UFC's strawweight division. She was expected to make her UFC debut against Valerie Letourneau at UFC 206, but was forced to pull out due to injury. She was replaced by former opponent and fellow XFC champion Viviane Pereira. Botelho fought Pearl Gonzalez at UFC 216 on October 7, 2017. She won the fight via unanimous decision. Botelho faced Syuri Kondo on May 19, 2018 at UFC Fight Night 129. She won the fight via TKO due to a body kick and punches just 33 seconds into the first round. Botelho faced Cynthia Calvillo on November 17, 2018 at UFC Fight Night 140. At the weigh-ins, Calvillo weighed in at 118 lbs, 2 pounds over the strawweight non-title fight limit of 116 lbs. She was fined 20 percent of her purse, which went to her opponent, Botelho, and the bout proceeded at catchweight. She lost the fight via a rear-naked choke in round one. Botelho was briefly linked to a matchup with Paige VanZant at UFC 236 on April 13, However, just days after the pairing was leaked, VanZant announced that she would not be competing on the card due to a fractured right arm. VanZant was replaced by Lauren Mueller. She won the fight by unanimous decision. Botelho was scheduled to face Maryna Moroz on August 17, 2019 at UFC 241. However, it was reported on August 1, 2019 that Moroz was forced to pull from the event, citing injury. It is unclear at the moment if a replacement would be sought. Botelho is scheduled to face Gillian Robertson on October 17, 2020 at UFC Fight Night 182.
