De Ram entered the seminary at Mechelen, where he was ordained in 1827. He was appointed professor of poetry at the seminary of Mechelen and archivist of the diocese. During the period when King William I was carrying on his campaign against the Catholic faith and traditions of the Belgians, and while de Ram was still young, he took an active part in the struggle maintained by the Belgian clergy against the government of the Netherlands, republishing eighteenth century works, in which, in a series of historical studies refuting the doctrines of Joseph II, he combatted the latter's disciple, King William I. He was next appointed keeper of the diocesan records and professor in the episcopal seminary at Mechelen. In order to stay the spread of Protestantism in the Netherlands he collaborated with a movement for the publishing of religious works, bringing out Levens van de voornaemste Heyligen en roemweerdige peersonen der Nederlanden. His chief study for many years was hagiography, and he published an edition of Butler'sLives of the Saints. Between 1828 and 1858 appeared the Synodicon Belgicum, a collection of unpublished documents upon the ecclesiastical history of the Netherlands since Philip II. During the years immediately before the Revolution of 1830, de Ram, who was much influenced by Lamennais, was active in bringing about a coalition of Liberals and Catholics against the Dutch government established by the Powers on the fall of Napoleon, and in endeavoring to give a democratic character to the policy of his church. He declined to stand as a member of the Belgian assembly, and applied himself wholly to teaching and to editing or composing historical books. De Ram was an active member of the Royal Academies for Science and the Arts of Belgium and a foreign associate of the Bavarian Academy of Sciences and Humanities. When the monumental project of the Acta Sanctorum, interrupted in 1794, was resumed by the so-called New Bollandists in 1838, De Ram, who as a young man had bought the whole corpus – to this time 53 volumes in folio – and who himself was considered as a possible member of the board of editors, gave his expert opinion to the Commission royale d’histoire of the Royal Academy recommending warmthly the prosecution of the much discussed project. As professor of philosophy at Mechelen he succeeded in bringing about the foundation of the Catholic University of Mechlin in 1834. This new university stayed only briefly in Mechelen, as the bishops already moved the university headquarters to Leuven on 1 December 1835, where it took the name Catholic University of Leuven, after the suppression of the State University of Leuven, where many professors from the old university had taught. This led to further consternation among the Belgian liberal society, which was afraid to see this new university usurp the past of the former Old University of Leuven. It also reinvigorated demands for the foundation of a secular university in Brussels which would lead to the foundation of the Free University of Brussels. De Ram was rector of the new Catholic University of Louvain founded in Mechlin in 1834 till his death in 1865.
