Phosphatidylinositol 3-kinase-related kinase


Phosphatidylinositol 3-kinase-related kinases are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases.

Members

The human PIKK family includes six members:
GeneProteinFunction
ATMataxia-telangiectasia mutatedresponse to DNA damage
ATRataxia- and Rad3-related"
PRKDCDNA-dependent protein kinase catalytic subunit "
MTORmammalian target of rapamycin nutrient-regulated kinase that controls metabolism and cell growth
SMG1suppressor of morphogenesis in genitaliaregulates nonsense-mediated mRNA decay
TRRAPtransformation/transcription domain-associated proteintranscription factor co-activator

Structure

PIKKs proteins contain the following four domains:
  1. N-terminus FRAP-ATM- TRRAP domain,
  2. kinase domain,
  3. PIKK- regulatory domain, and
  4. C-terminus FAT-C-terminal domain