Pelswick Eggert - A 13-year-old boy who uses a wheelchair. How he became a paraplegic is not revealed in the series, but the series' creators imply through commentary that it was due to a car accident. He dislikes it when people treat him differently because of his disability. He dislikes following the crowd and he goes by his own rules.
Ace Nakamura - Pelswick's best friend. Ace is technologically smarter than any of his friends, and is often the thinker of the situation.
Goon Gunderson - Pelswick's other best friend. Huge and slow-witted in his actions and thoughts, Goon is generally good-hearted but rather dangerous when angry. He does not know that wrestling is staged.
Julie Smockford - A redheaded girl and one of Pelswick's friends. She hates all the cliques and popularity contests at school and seems to care mostly about her popularity and image. Julie is smart, dramatic, sometimes annoying, but cares a lot about Pelswick. Pelswick has a crush on her but she’s completely oblivious about it. Julie believes in justice for all.
Sandra Scoddle - Julie's snooty and arrogant best friend/rival and one of Pelswick's friends. She thinks she's better than everyone else and often disputes with Julie. She thinks she’s cool, but she's not. She gets caught into the latest trends.
Mr. Jimmy - Pelswick's guardian angel who often gives him advice that confuses him until the last moment, no matter what it is. Pelswick can't stand him and his issues. He is also the comic relief of the show.
Kate Eggert - Pelswick's precocious younger sister. She treats her reputation as a little sister like a business and usually blackmails Pelswick when butting into his business. She has dreams of owning a big corporation. She is 10 years old, but she is a 5th grade elementary student.
Bobby Eggert - Pelswick's and Kate's baby brother. He dosen’t talk and admires Pelswick. Given that Pelswick and Kate's mother is unseen, it can be assumed Bobby is either adopted or is the child of a relative that their father is taking care of.
Quentin Eggert - Pelswick, Kate and Bobby's politically correct father who works as a college professor until he’s fired in "The Case of the Filched Files." He later gets his job back. He wants to do everything by papers. His wife is unseen, however it can be assumed that she’s working abroad or Quentin is either divorced or widowed.
Priscilla "Gram-Gram" Eggert - Quentin's mother and Pelswick, Kate and Bobby's deranged grandmother. She often does "extreme" acts beyond that of a grandmother. Most of these acts results in her getting arrested.
Boyd Scullarzo - The bully of Pelswick's school who likes bullying Pelswick and others, not physically but with humiliation.
Vice Principal Ziegler - The vice principal of Jr High. Despite his title, he usually assumes the role of a principal. Throughout the show, there is no mention of there being a principal at Jr High. During the second episode of the series, this issue was lampshaded by Goon Gunderson who questioned why their school had a vice principal but no principal.