Kuo-hsi was born in Puyang, Zhili province of China. He joined the Society of Jesus on September 11, 1946, took religious vows, September 12, 1948, and final vows on February 2, 1963. He was ordained on March 18, 1955, in Baguio, Philippines. He attended St. Joseph Regional Seminary, Chiughsien and then Berchmans College, Manila, where he earned a licentiate in philosophy. He went on to attend Bellarmine College, Baguio, Philippines, being awarded a licentiate in theology. He also attended the Xavier University earning a diploma in education science and finally the Pontifical Gregorian University in Rome where he was awarded a doctorate in theology. Besides Mandarin, his first language, he also spoke Latin, English, French, Italian, Spanish and Portuguese. After his ordination to the priesthood in 1955, he did further studies in Novaliches from 1955–1957. He then served as director of the Chinese section of Sacred Heart School, Cebu from 1957–1959, after which he took time to pursue doctoral studies in Rome. He served as assistant master of novices, Thuduc, Vietnam, from 1959–1963, then master of novices and rector of Manresa House, Changhua, Taiwan from 1963–1970. He went on to serve as rector of St. Ignatius Institute in Taipei from 1970–1976 and president of the Catholic Schools Association, Taiwan, from 1972–1976. He was appointed episcopal vicar of Taipei in 1976, holding the post until 1979. He was appointed Bishop of the Roman Catholic Diocese of Hualien, in Hualien, Taiwan, on November 15, 1979, by Pope John Paul II, and after his episcopal consecration was installed as Bishop of Hualien on February 14, 1981. After his service there, he was transferred and appointed Bishop of the Roman Catholic Diocese of Kaohsiung, in Kaohsiung, Taiwan, also by Pope John Paul II, on March 4, 1991. He was installed as Bishop of Kaohsiung on June 17, 1991. He was appointed Cardinal-Priest of the Titulus S. Chrysogoni by Pope John Paul II on February 21, 1998, and was, following the death of Cardinal Ignatius Kung in 2000, and then Cardinal John Wu in 2002, and before the elevation of Cardinal Joseph Zen, the only known living Chinese Cardinal. He retired in January 2006 and died on Wednesday, August 22, 2012, after a battle with a pneumonia infection, having also battled lung cancer since his diagnosis in August 2006, eight months after his retirement.