Paul Lewi Paul J. Lewi was a Belgian scientist, who elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics in 1983. Paul Lewi was married with Godelieve Debruyne and they have together 3 children and with Philomena Van Bylen, with 2 children.Biography Paul Lewi was born in 1938 in Westmalle , Belgium . His parents, Leo Lewi and Mariette Devocht, were professional artists and teachers. He graduated as Industrial Engineer in Nuclear Chemistry at the Hoger Rijksinstituut voor Technisch Onderwijs en Kernenergiebedrijven Mol , in 1960 and as a Candidate in Mathematical Sciences at the Catholic University of Leuven in 1962. He obtained a PhD in Pharmaceutical Sciences at the Vrije Universiteit Brussel in 1995. He started working at Janssen Pharmaceutica in 1962, first as mathematical analyst in Cardiovascular Research , then he became the head of Applied Mathematics in 1967, and head of the Scientific Computer department in 1969. He became head of the Information Science department and finally vice-president of the Center for Molecular Design in 1995, which he founded together with Paul Janssen . During his career he elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics in 1983. He is named as co-inventor of a novel series of anti-HIV compounds including dapivirine , etravirine and rilpivirine . After his retirement he served as visiting professor at the Universities of Leuven, Antwerp and Brussels.Publications Books: Lewi P.J.. Multivariate data analysis in industrial practice. Research Studies Press, John Wiley & Sons , Chichester etc., 1982,. Lewi P.J.. Spectral mapping of drug-test specificities with extensions to the classification of receptor proteins and the correlation of activity spectra. Vrije Universiteit Brussel , Brussel, 1995, proefschrift faculteit geneeskunde en farmacie. D.L. Massart, B. Vandeginste, L. Buydens, S. De Jong , P. Lewi and J. Smeyers-Verbeke, Handbook of Chemometrics and Qualimetrics. Vol 20 A,, Elsevier. B. Vandeginste, D.L. Massart, L. Buydens, S. De Jong, P. Lewi and J. Smeyers-Verbeke, Handbook of Chemometrics and Qualimetrics. Vol 20 B,, Elsevier. Articles, a selection: Lewi P.J.. "Spectral mapping, a technique for classifying biological activity profiles of chemical compounds . Arzneim. Forsch". in: Drug Res. 26, 1295–1300. Lewi P.J.. "Multidimensional analysis of pharmacological data". In: Rev Pure Appl Pharmacol Sci. 1981 Jul–Sep;2:229-90. Lewi P.J.. "The use of multivariate statistics in industrial pharmacology". In: Pharmacol Ther . 1978;3:481–537. Lewi P.J.. "Spectral Map Analysis. Factorial analysis of contrasts, especially from log ratios." In: Chemometr. Intell. Lab. Syst. , 5, 105–116, 1989. Lewi P.J, Mullie A, Quets A.. "Relevance and significance of pre-CPR conditions in cardio-pulmonary-cerebral resuscitation. A graphic analysis by means of Spectramap". The Cerebral Resuscitation Study Group , Resuscitation. 1989;17 Suppl:S35-44; discussion S199-206. Lewi P.J.. K. Andries, B. Dewindt, J. Snoeks, L. Wouters, H. Moereels, P.J. Lewi, "Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity". In: J Virol , 64, 1117–1123, 1990. Lewi P.J.. "Spectral mapping, a personal and historical account of an adventure in multivariate data analysis". In: Chemometr. Intell. Lab. Syst. , 77, 215–223, 2005. 2006. .
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