Pizzella worked as a political field staffer for Ronald Reagan's 1976 campaign for the Republican presidential nomination, then spent four years, from 1977 to 1980, as executive director of right-to-work committees in New Mexico and Delaware.
Reagan administration, 1981–1989
From 1981 to 1982, Pizzella served on the staff of the General Services Administration, and from 1983 to 1985, he was the special assistant to the Administrator of the GSA. In 1985, he became special assistant to the Associate Deputy Administrator for Management and Administration at the Small Business Administration. In 1986, Pizzella served as Director of Intergovernmental and Regional Affairs at the SBA. From 1986 to 1988 he served as Administrator for Management Services, and from 1988 to 1989, he was the Deputy Under Secretary for Management, both at the United States Department of Education. Pizzella's stay at the Education Department was short-lived, as he and several other conservative Reagan appointees resigned in March 1989, in a move hailed by liberals as a return to "collaborative efforts between the special-interest groups and the Department of Education" following William J. Bennett's tenure. However, Pizzella was not replaced, and his Senate nomination withdrawn, until September 1989.
In 1989, Pizzella was recruited by HUD Director Jack F. Kemp to serve at the new Federal Housing Finance Board, created as part of the 1989 savings-and-loan bailout legislation, to oversee the 12 Federal Home Loan Banks and channel some of their profits into housing programs. Pizzella served first as a consultant, then for five years.
Private sector, 1996–2001
Pizzella worked at Preston Gates Ellis & Rouvelas Meeds LLP as director of coalitions from 1996 to 1997, and as government affairs counselor from 1998 to 2001. Though he worked for lobbyist Jack Abramoff at Preston Gates, he was not among the 21 Abramoff associates who were convicted of or pleaded guilty to wrongdoing in connection with their work. During this time, he contributed to Heritage Foundation policy development on civil service reform.
Pizzella ran his own consulting firm and was principal at Patrick Pizzella LLC, a position he held from 2009 to 2013. He was cited in an editorial by The Wall Street Journal, and authored articles in the Washington Examiner, The American Spectator, Government Technology magazine, and GCN magazine.
In August 2013, President Barack Obama nominated Pizzella to fill the Republican position on the three-member Federal Labor Relations Authority; he was confirmed by the U.S. Senate on October 16, 2013. Pizzella was nominated again by Obama for the same position in November 2015, for a five-year term ending July 1, 2020, but the Senate failed to act on the nomination by the time it adjourned in January 2017, and the nomination expired. On January 23, 2017, Pizzella was designated by President Donald Trump to be the Acting Chairman of the FLRA.
On June 19, 2017, Trump announced his intent to nominate Pizzella to be the next United States Deputy Secretary of Labor, replacing acting Deputy Secretary Nancy Rooney. On June 20, 2017, his nomination was sent to the United States Senate. After the end of the 2017 congressional session, Pizzella's nomination was re-delivered to the Senate in January 2018, and was referred to the United States Senate Committee on Health, Education, Labor and Pensions. Cloture was invoked on Pizzella's nomination on April 11, 2018, and he was confirmed as Deputy Secretary on the following day; both the cloture and the vote on the nomination passed by 50–48 votes in the Senate.
Acting Secretary of Labor
On July 12, 2019, following the resignation of Secretary Alex Acosta, Trump announced via Twitter that Pizzella would serve as acting Secretary of Labor. Trump nominated Eugene Scalia to succeed Acosta, and he was sworn in on September 30, 2019.
Personal life
Pizzella is married to Mary Joy Jameson, former senior business development executive for Google, a senior public affairs aide in the Reagan, George H.W. Bush, and George W. Bush administrations, now serving on the Clemson University Foundation Board. They live in Alexandria, Virginia, and Pinehurst, North Carolina.