Born in Newtown Square, Pennsylvania, Chambers played collegiate basketball at Philadelphia University. Despite joining the team without a scholarship, he left it as the starting point guard and the team record-holder in assists. He is currently 7th all-time in steals and led the team to four NCAA Division II Sweet 16 appearances and two Elite Eight finishes. Chambers took over for Dennis Wolff as the head coach at Boston University following the 2008–09 season. He was previously the associate head coach at Villanova University. He started at Villanova as director of operations in May 2004. He was promoted to assistant coach after one season and finally Associate Head Coach in June 2008. Prior to Villanova, Chambers was an assistant at Philadelphia University, Delaware Valley College and Episcopal Academy. In his first season at BU, Chambers led the Terriers to a 21–14 overall record and an 11–5 mark in league play. The Terriers fell just short of an America East Tournament Championship after falling to University of Vermont 83–70 on March 13, 2010. The team did qualify for the 3rd annual College Basketball Invitational and won their first postseason game since 1959. They also hosted the first postseason game in program history, defeating Morehead State University in overtime at Case Gymnasium. In Chambers' second season at Boston University, he again led the Terriers to a 21–14 overall mark, including a 12–4 mark in conference play. They defeated Stony Brook University at Agganis Arena to win their sixth conference title and clinch an automatic bid into the NCAA Tournament. They received a #16 seed and fell to the #1 seed Kansas Jayhawksin the round of 64 by a score of 72–53. The game marked the Terriers' first appearance in the NCAA tournament since 2002. Penn State announced Chambers as the 12th head coach in Nittany Lion basketball history in June 2011. The best season Chambers has had at Penn State so far has been 2017-18 where the team finished 26-13 and its highest Big Ten finish in his tenure. The season was highlighted with 3 wins over Ohio State and a 2018 NIT Championship. However, in 2019 Chambers had the team ranked at #23 for their first AP appearance since 1996 after a win over then #4 ranked Maryland and a hot 10-2 start. Chambers and his wife Courtney have four children: Grace, Ryan, Caitlyn, and Patrick.
