He studied under Satya Shodhak Samaj of Mahatma Phule. He did satyagraha to allow untouchables to enter Ambabai Temple, Amravati, which was condemned by the upper castes. Dr. Bhimrao Ramji Ambedkar supported him in this movement. The management of the temple later allowed untouchables to enter the temple. Dr. Punjabrao Deshmukh started another equality movement from his home. After the death of his father, his mother asked him to conduct traditional activity "Shradhha" with Brahmins. He brought untouchable students home from his school hostel and his mother treated them as Brahmins. His marriage ceremony was simple and held in Mumbai. After the marriage ceremony, when he reached Amravati, his friends convinced Deshmukh to give a party. He held a small dinner party for them. The meal was served by youths wearing white. After dinner Bhausaheb stated that the servers were untouchables. Many such events were conducted by Dr. Deshmukh to remove untouchability from our society.
Educational activist
In 1931 he established Shivaji Education Society at Amravati. This education society grew to become the second largest in Maharashtra. This society operates 24 degree colleges, 54 intermediate colleges, 75 high schools, and 35 hostels. An agricultural university bearing his name operates at Akola, i.e. Panjabrao Deshmukh Krishi Vidyapeeth. He strengthened the foundation of education throughout Maharashtra.
Politics
He was elected thrice for the Lok Sabha. Dr. Deshmukh was selected by Nehru as India's first agriculture minister. He played an important role in the making of the Indian Constitution. He inspired by B. R. Ambedkar and was a supporter of the mission by Dr. Babasaheb Ambedkar. He was the secretary for Vidarbha region of the Independent Labour Party, established by Dr. Babasaheb Ambedkar.
Leader of peasants
He dedicated his talent and energy for the formulation and implementation of the policies that would bring prosperity to agriculture and the agriculturist. He established the Bharat Krishak Samaj and launched a campaign called Food for Millions in 1955. He introduced the Japanese method of rice cultivation in 1958 and organized the World Agriculture Fair in 1959. The fair was visited by dignitaries across the world, including US President Dwight Eisenhower, USSR President Nikita Khrushchev, Lord and Lady MountBatten. He started the process of establishing agricultural universities across the country and supported agricultural education and research.
Lawyer
He appeared for poor peasants in many cases at the district court of Amravati. His most predominant case was British Government vs. Azad Hind Sena, in which he assisted Jawaharlal Nehru.