PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha is an enzyme that in humans is encoded by the PAFAH1B1 gene. The protein is often referred to as Lis1 and plays an important role in regulating the motor protein Dynein.Function
PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller–Dieker syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.
According to one study, PAFAH1B1 interacts with VLDLR receptor activated by reelin.Genomics
The gene is located at chromosome 17p13.3 on the Watson strand. The gene is 91,953 bases in length and encodes a protein of 410 amino acids.Interactions
PAFAH1B1 has been shown to interact with DYNC1H1, CLIP1, NDEL1, NDE1, PAFAH1B3, PAFAH1B2, NUDC, TUBA1A and Doublecortin.
