Oxamate
Oxamate is a salt of oxamic acid. Oxamate has a molecular formula of C2H2NO3− an isosteric form of pyruvate. Oxamate is a noncompetitive inhibitor of the enzyme lactate dehydrogenase. Oxamate is a possible pyruvate analog that has the ability to halt lactate production by inhibiting lactate dehydrogenase, effectively stopping the conversation process of pyruvate to lactate.
Oxamate plus Phenformin has been tested in conjunction with one another and it was shown that this combination has potential anti-cancer properties. Phenformin when administered by itself has a high incidence of lactic acidosis. Due to the inherent ability of Oxamate to prevent the conversion of pyruvate to lactate, oxamate can be used to counter balance the side effects of Phenformin.
Oxamate also plays inhibiting roles with Oxaloacetate, an important intermediate for the Citric acid cycle. Oxamate competes and binds to the Carboxyl transferase domain active site, and reverses the reaction of oxalaoacetate decarboxylation by Pyruvate carboxylase.
