Hintze was born in the small town of Pyritz in the Province of Pomerania, the son of a civil servant. From 1878 to 1879, Hintze studied history, philosophy and philology in Greifswald. Here he joined the fraternity Germania. Hintze came to Berlin in 1880, and soon obtained a doctorate under Julius Weizsäcker with a dissertation on Medieval History in 1884. He joined the project on the ‘Acta Borussica’, an editing project of the Prussian Academy of Sciences under the directorship of Gustav Schmoller dealing with the Prussian administrative files of the 18th century. Seven volumes of sources on the economics and administrative organisation in Prussia, with detailed historical commentaries, were published by 1910. In 1895, his post-doctoral thesis to become a lecturer was accepted by Treitschke and Schmoller; in 1902 as Professor of the newly created Department of Political, Constitutional, Administrative and Economic History. In 1912, Hintze married his student Hedwig Guggenheimer. One of his key works, Die Hohenzollern und ihr Werk, is considered to be an important and solidly researched piece of scholarship, despite having been commissioned by the Prussian Hohenzollern dynasty for their ruling anniversary in 1915. Hintze was prematurely retired from the university in 1920 due to health reasons. Hintze ceased publishing after the Nazi Party came to power and, in 1933, he was the only member to speak against Albert Einstein's expulsion from the Prussian Academy of Sciences. In 1938, Hintze himself resigned from the Academy, which he had been a member of since 1914. His wife, Hedwig Hintze, who was Germany's first woman to receive a doctorate in History and the University of Berlin's first woman History professor, because of her Jewish roots and leftist sympathies soon lost her position as lecturer at the Friedrich Wilhelm University, and eventually had to flee to the Netherlands in 1939. Otto Hintze only survived this separation for a few months. In 1942, his wife committed suicide rather than undergo deportation to a death camp by the Nazis. Since the 1960s, there has been deeper research into Hintze's oeuvre, as signified by Gerhard Oestreich’s detailed new work on him. The historians Jürgen Kocka and Felix Gilbert agree that, in their opinion, he could possibly be the most significant German historian of the German Empire and of the Weimar Republic.