David, a 29-year-old gay man, moves home to Sacramento to take care of his mother, Joanne, who's in the advanced stages of leiomyosarcoma. Being home is further complicated by his conservative, religious family and his father's refusal to accept his sexuality, ten years after he came out. As Joanne struggles through chemo, decides to quit treatment, and begins to decline, each of the family members deal with the inevitable loss in their own way.
The film is loosely based on Kelly's own mother's death in 2009. Kelly chose to deliberately start the film by showing Molly Shannon's character dying "because I didn’t want the movie to be about, 'Well, does she or doesn’t she?'" also noting that it sets the tone for the rest of the movie. Shannon was an early choice for Kelly although his managers expressed doubt about this happening from an early stage. Kelly noted that Shannon in the film resembles his actual mom stating "I don’t look at the movie and see my dad as that, or myself, or my sisters, but I do see my mom, and it was kind of accidental," adding that he had felt weird directing her due to the similarities. Sissy Spacek was originally attached to play Joanne.
Other People received positive reviews from critics. It holds an 85% approval rating on review aggregator website Rotten Tomatoes, based on 59 reviews, with an average rating of 7.1/10. The site's critical consensus reads, "Other People resists easy melodrama, rewarding viewers with a smart, subtle look at family dynamics with a talented cast and a finely calibrated blend of funny and serious moments." On Metacritic, the film holds a rating of 68 out of 100, based on 23 critics, indicating "generally favorable reviews". In its review of the film, The Hollywood Reporter stated, "Ably playing the loving son, a comedy writer quietly worrying that his life is falling apart even without having Mom's cancer in the picture, Jesse Plemons delivers on the promise he has shown in so many supporting roles since his Friday Night Lights breakthrough." New York magazine praised Shannon's performance and the supporting performance of Josie Totah, describing his performance as follows: "The child actor is only featured in two of Other People’s scenes—he plays the flamboyant younger brother of Plemons’s best friend—but he makes the goddamn most of them: Totah waltzes into his first scene casually hitting on the far-older Plemons, then spends his second scene in drag, staging an over-the-top, twerk-filled performance for his bemused family."
