His first musical trio had the name of "Los Hijos del Paraguay". Towards the end of 1962, the group left to Foz do Iguaçu, Brazil. Once located there, they started a series of presentations at some of the local restaurants, which allowed them to cover their daily expenses. From Foz do Iguaçu, they went to Curitiba, capital of the Paraná state. With an improvised album, made of eight pictures taken at a nearby lab in the bus terminal, they left to look for a job in the big city. They mainly looked at restaurants and barbecue places, so as to get at least a good meal each day. They also went to newspapers, radio stations, and the only TV channel of Curitiba at that time. It was there that they finally made a series of presentations for a program directed by Kat Maia, a TV program presenter. By then, the group's name was "The Three Suns" and besides Safuán was also Dario Duarte, and Antonio Gill. Safuán eventually established himself in São Paulo. There, the group made contact with other Paraguayan artists who were living in that city, such the case of Luis Bordón, Papi Galan and Americo Pereira, the latter with whom Safuán studied theory. He also studied with Rufo Herrera and Luis Pecora. At the same time, he dedicated himself to making musical arrangements at disco houses and to the presentations of the group. Later, he continued studying with different masters. Safuán founded a music school, "Los Amigos", where he taught other Paraguayans to read music. He was questioned by the evolution of the folk music of his country, and in 1974 he started a research on it, and elaborated the basis for a projection proposal, developing rhythmic combinations as well as melodic ones, in base of the fusion of the guarania and the Paraguayan polka. In 1977 he presented in Asunción his new rhythm named Avanzada, applied to his first composition: "Tema Paraguayo". This musical innovation was supported by important people of the Paraguayan musical sphere, among them, Mauricio Cardozo Ocampo, but the Avanzada had also people against it.
According to Safuán, " is neither polka nor guarania. It is anew rhythm generated by both, and as the child, has a life and a light of his own." In this musical style, Safuán incorporated, besides folk rhythms, electronic instruments, and influences from popular Brazilian music such as bossa nova and ballade.