In May 1821, Omer Vryonis, the commander of the Ottoman army, advanced with 8,000 men, after crushing the resistance of the Greeks at the river of Alamana and putting Athanasios Diakos to death, headed south into the Peloponnese to crush the Greek uprising. Odysseas Androutsos with a band of 100 or so men took up a defensive position at an inn near Gravia, supported by Panourgias and Diovouniotis and their men. Vrioni attacked the inn but was repulsed with heavy casualties. Finally, he was forced to ask for reinforcements and artillery, but the Greeks managed to slip out before the reinforcements arrived. Androutsos lost six men in the battle and earned the title of Commander in Chief of the Greek forces in Central Greece. In the following year, May 1822, he clashed with political opponentIoannis Kolettis and the Areopagus of Eastern Continental Greece. He was accused for collaboration with the Ottomans and the government dismissed him from commander. However, soon, he was restored and kept command in Eastern Central Greece. In September 1822, Androutsos, on the instances of the Athenian municipal authorities, with Gouras and Makrigiannis took control of the Acropolis in Athens which had capitulated in June. To ensure the occupation he had a bastion built to protect the ancient Klepsydra spring, which had just being rediscovered by chance on the north-western slope of the rock. During the next year, he passed to Euboea to fight against and clear it from Turks.
Downfall
In early 1825, as the Greek Govermment still wanted to take the command of him and replace him, Androutsos, in anger, began a correspondence with Omer Pasha of Karystos, offering to hand over the Acropolis if aided by Ottoman troops and placed in control of the districts of Livadia, Thebes, and Atalanti. Though the terms of their agreement are not preserved in Ottoman archives, Androutsos was sent a firman granting him amnesty. He joined forces with the Ottoman army to defend the villages around Livadia. After promised reinforcements failed to arrive, he retreated but was captured by Greek insurgents. The revolutionary provisional government placed him under arrest in the Frankish Tower of the Acropolis of Athens, accusing him again for collaboration with the Ottomans. The new commander, Yannis Gouras, who once was Androutsos' second in command, ordered his execution on June 5, 1825. Gouras didn't bring him in fair trial, believing that Androutsos, due to his democratic character, could turn the people against the Govermment. Androutsos' sister Tersitsa married Edward John Trelawny, who commanded Androutsos' forces in his absence.