OSBPL3
Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.Function
This gene encodes a member of the oxysterol-binding protein family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.Model organisms
s have been used in the study of OSBPL3 function. A conditional knockout mouse line called Osbpl3tm1aWtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
