O'Donohue
O'Donohue is a surname, and may refer to:
- Becky O'Donohue, reality television participant
- Daniel Anthony O'Donohue, United States Ambassador to Burma
- Edward O'Donohue, Australian politician
- Jessie O'Donohue, reality television participant
- John O'Donohue, poet and philosopher
- John F. O'Donohue, American actor
- Michael O'Donohue, Irish-American builder and architect
- Peter O'Donohue, former Australian rules footballer
- Ryan O'Donohue, American voice actor
- Tony O'Donohue, Canadian politician
- William O'Donohue, American psychologist
