Nucleotide exchange factor
Nucleotide exchange factors are proteins that stimulate the exchange of nucleoside diphosphates for nucleoside triphosphates bound to other proteins.Function
Many cellular proteins cleave nucleoside triphosphates-adenosine triphosphate or guanosine triphosphate -to their diphosphate forms as a source of energy and to drive conformational changes. These changes in turn affect the structural, enzymatic, or signalling properties of the protein.
Nucleotide exchange factors actively assist in the exchange of depleted nucleoside diphosphates for fresh nucleoside triphosphates. NEFs are specific for the nucleotides they exchange and are often specific to a single protein or class of proteins with which they interact.
