In 1968 during a big student revolt in the streets of Belgrade, he daily criticized official press coverage of the protests in front of hundreds of protesting students. For this reason he was denounced by semi-official newspaper Politika. He was a leading anti-Marxist intellectual in Serbia during the 1970s and 1980s. In the 1970s he criticized severely Vladimir Lenin's involvement in pre-revolutionary robberies and this had powerful echo and undermined pro-Marxist intelligentsia in Yugoslavia that supported the government of Josip Broz Tito. In his 1985 book Marxism and Jesuitism he severely criticized Lenin and Joseph Stalin, which prompted Soviet officials to unsuccessfully demand his removal from the University of Belgrade. He continued his anti-communist involvement during the rule of Slobodan Milošević and was eventually banned from entering the Faculty of Philology building in 1998 by a government-appointed dean. Nikola Milošević's lectures at the Faculty of Philology were attended by the who is who of intellectual Belgrade and his polemics with Marxist authors attracted considerable attention. In 1982, he declined to accept the highest communist award of the City of Belgrade for scholars and artists – the October Prize. In political sphere he was a conservative liberal. He was one of the founders of the re-established Democratic Party in Serbia in 1990. After quarrels with party's leader prof. Dragoljub Mićunović, Nikola Milošević, together with a group of ten prominent members of the Democratic Party, established a new party – the Serbian Liberal Party. This party advocated liberal and anti-communist ideas and boycotted all elections during the reign of Slobodan Milošević. In 2003 Nikola Milošević became a member of the Serbian Parliament since the Serbian Liberal Party participated in December 2003 elections as a coalition partner of the Democratic Party of Serbia. His last publication was a collection of political polemics entitled Politički spomenar: Od Broza do DOS-a .
Philosophical orientation
He was dedicated to philosophical anthropology and the problems of human nature. He attempted to establish a new subdivision of philosophical anthropology which he named psychology of knowledge and elaborated in detail on this discipline in his books Psychology of Knowledge and Philosophy and Psychology. Overall he was an anthropological pessimist.