Neurotrophic factor receptor


Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins.
Two classes of neurotrophic factor receptors are the p75 and the "Trk" families of Tyrosine kinases receptors.
mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling.
There are other related Trk receptors, and there are other neurotrophic factors structurally related to NGF
The other NGF receptor, the LNGFR, can elicit apoptosis of cells that are positive for the LNGFR and negative for TrkA.
Secreted proNGF has been demonstrated in a variety of neuronal and non-neuronal cell populations. It has been proposed that secreted proNGF can elicit neuron death in a variety of neurodegenerative conditions, including Alzheimer's disease, following the observation of an increase of proNGF in the nucleus basalis of postmortem Alzheimer's brains.