Nessus is known for his role in the story of the Tunic of Nessus. After carrying Deianeira, the wife of Heracles, across the river, he attempted to force himself upon her. Heracles saw this from across the river and shot a Hydra-poisoned arrow into Nessus's breast. As he lay dying, as a final act of malice, Nessus told Deianeira that his blood would ensure that Heracles would be true to her forever, knowing the blood to be infected with the hydra's poison. Deianeira foolishly believed him. Later, when her trust began to wane because of Iole, she spread the centaur's blood on a robe and gave it to her husband. Heracles went to a gathering of heroes, where his passion got the better of him. Meanwhile, Deianeira accidentally spilled a portion of the centaur's blood onto the floor. To her horror, it began to fume by the light of the rising sun. She instantly recognized it as poison and sent her messenger to warn Heracles but it was too late. Heracles lay dying slowly and painfully as the robe burned his skin—either in actual flames or by the heat of poison. He died a noble death on a funeral pyre of oak branches. Heracles was then taken to Mount Olympus by Zeus and welcomed among the gods for his heroic exploits. A similar theme appears in certain versions of the story of Medea. Sophocles' play Trachiniae is extensively based on a retelling of this myth.
Nessus appears as an antagonist in the Disney movieHercules voiced by Jim Cummings. In the film, he is portrayed as a lecherous river guardian and is Hercules's first major opponent. Hercules defeats him in battle and saves Megara from him, but it is later revealed that Megara had been sent by Hades to recruit Nessus for his cause. Nessus appears in the video game based on the film and serves as the game's first boss, in the episode Hercules and the Arabian Night as Hades's Chess-board Piece from the animated series bases on the film and in the episode Salute to Sports as cameo from the TV seriesHouse of Mouse.
One of the main characters in Larry Niven'sseries of books from the Ringworld universe is called Nessus. He is of an alien race with a three-legged body similar to an ostrich without feathers and two snake-like heads on long necks.
Nessus appears in ' voiced by Charlotte Cornwell. This version is depicted as a female and is a good friend of Virgil. She helps Dante and Virgil across the Phlegethon.
The episode is the basis for a section of T.S. Eliot's Four Quartets, , mirroring the greater theme of the poem.
Nessus appears as a boss character in the 2006 video game Titan Quest.
Nessus is the name of the Centaur setting of a playable location in the 2017 video game Destiny 2. It is also mentioned in a grimoire card in the first game of the series, where Cayde-6 comes across a mention of the planetoid's erratic motions while searching the Tower's database, leading him to enter the queries "did we get invaded by horse people?" and "did horse people ever exist?"
Nessus also appears as a boss character in the 2008 video game Rise of the Argonauts.