In June 2018 Calviño was chosen by Prime Minister Pedro Sánchez to be part of his new government as Minister of Economy and Business of Spain, following the motion of censure that the PSOE presented against the previous government of Mariano Rajoy and that was approved by the Congress of Deputies on 1 June 2018. Thus, on 7 June she took office as Minister of Economy and Business before the King at Palace of Zarzuela. Following the resignation of Christine Lagarde as managing director of the International Monetary Fund in 2019, Calviño was one of the candidates considered by European governments as potential successor; she withdrew after a first round of voting among representatives of the EU’s 28 member states and the post went to Kristalina Georgieva instead.
In early 2020, the COVID-19 pandemic expanded to Europe, reaching Spain in late January. In March, Calviño announced a 200-billion-euro package to fight the economic effects of coronavirus, which included loans and guarantees to self-employed and to small and medium-sized entreprises and large companies. Although Calviño initially opted for Eurobonds, due to the reluctance of some European countries, she adopted a more pragmatic position and she proposed to use the European Stability Mechanism but without conditions, an option accepted by the European Council which allowed the unlocking of €500 billion funds to the most affected European states. However, Calviño stated that neither she nor the government renounced Eurobonds and that they will continue to work on them in the medium term. In mid-April, Calviño proposed to its European counterparts a 1.5 trillion euro recovery fund, that would be financed through perpetual debt issued by the European institutions.
In Mid-June 2020, rumors increased about a possible candidancy of Calviño to be the next president of Eurogroup. Spanish Prime Minister declared that Spain would be "very interested" on it. The Spanish government officially proposed Calviño on June 25. Calviño quickly received the support of the majority of the opposition in the Spanish Parliament. The first european government to show support to Calviño's candidature was the German government through its chancellor, Angela Merkel, who stated that "It is no secret that there is support for Nadia Calviño’s candidature in the German government". She also added that she was "pleased when women get leading political roles, and the Eurogroup has never been headed by a woman.". In June 28, Portuguese PM António Costa also supported Calviño. In July 8, Italian PM Giuseppe Conte publicly supported her. A day later, French finance minister, Bruno Le Maire, did the same.
Personal life
Calviño is mother to four children. Among her hobbies are 1950s cinema and cooking. She speaks Spanish, English, French and German.