NLRP7


NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.

Function

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain, and a C-terminal leucine-rich repeat region. NALPs are implicated in the activation of proinflammatory caspases via their involvement in multiprotein complexes called inflammasomes.