NCOA6
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.Function
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.Interactions
NCOA6 has been shown to interact with:
- ASCL2 and
- Activating transcription factor 2,
- Androgen receptor,
- CREB-binding protein,
- DNA-PKcs,
- E2F1,
- EP300,
- Estrogen receptor alpha,
- Estrogen receptor beta,
- HBXIP,
- HIST2H3C,
- HSF1,
- Ku70,
- Ku80,
- Liver X receptor beta,
- MLL3,
- RBBP5,
- Retinoblastoma protein,
- Retinoic acid receptor alpha,
- Retinoid X receptor alpha,
- Src,
- TGS1,
- TUBA4A,
- TUBB,
- Thyroid hormone receptor alpha, and
- Thyroid hormone receptor beta.
