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N,N-Dimethylsphingosine
N
,
N
-Dimethylsphingosine
is an
inhibitor
of
sphingosine kinase
.
In
rats
with
neuropathic pain
, the
natural
metabolite
DMS
is unregulated in the
dorsal horn
.
Furthermore
, DMS
induces
mechanical
hypersensitivity
when
injected
into rats.