Mysterious bypassed maiden races, beginning her career in the Group Three Cherry Hinton Stakes over six furlongs at the Newmarket July meeting. She won the race from two opponents but did not appear again in 1972. Mysterious made her first appearance as a three-year-old in the Group Three Fred Darling Stakes over seven furlongs at Newbury Racecourse. She defeated the Irish-trained favourite Grasse by three quarters of a length to take the event, a recognised trial for the 1000 Guineas. At Newmarket Mysterious was ridden as usual by Geoff Lewis and started at odds of 11/1 for the 1000 Guineas, with the Cheveley Park Stakes winner Jacinth being made odds-on favourite. Lewis sent Mysterious into the lead two furlongs from the finish and she won decisively, beating Jacinth by three lengths. Her win gave Murless a sixth success in the race, setting a 20th-century record. At Epsom a month later, Mysterious started 13/8 favourite for the Epsom Oaks against nine other fillies. Lewis restrained the filly in the early stages, before moving up along the inside to take the lead in the straight. Mysterious retained her undefeated record, winning easily by four lengths from Where You Lead. Mysterious started 1/2 favourite for the Irish Oaks in July, but was beaten three lengths by the French-trained filly Dahlia. Later that month Dahlia was a six length winner of Britain's most prestigious all-aged race, the King George VI and Queen Elizabeth Stakes. In the Yorkshire Oaks in August, Mysterious won comfortably from Virunga, a French filly who had finished second to Dahlia in the Prix Saint-Alary. Mysterious failed to reproduce her best form in her remaining two starts. She started odds-on favourite for the Sun Chariot Stakes but was beaten by Cheveley Princess, her only rival in a two-runner race. In October she finished sixth in the Champion Stakes at Newmarket.
Retirement
Mysterious spent her breeding career in the United States where she was bred to leading stallions including Northern Dancer, Mr. Prospector and Nijinsky. She produced several winners, but nothing approaching top class. Her most successful descendant has been Quest, whose wins included the Clark Handicap.
Assessment and honours
Mysterious was given a Timeform rating of 127. In their book, A Century of Champions, based on the Timeform rating system, John Randall and Tony Morris rated Mysterious an "average" winner of the 1000 Guineas and Oaks.