Myles Ambrose was born on July 21, 1926 in The Bronx, New York. His father, Arthur Ambrose, was a stockbroker on Wall Street. His mother, Ann Campbell, was a singer. Ambrose was educated at the New Hampton School. He received his bachelor's degree in business administration from Manhattan College in 1948 and his law degree from New York Law School in 1952.
Career
Ambrose started his career as a lawyer in New York City. He served as an assistant United States Attorney for the Southern District of New York from 1954 to 1957. He joined the United States Department of the Treasury in 1957, when he was appointed as chief coordinator of law enforcement and he prosecuted gang members. From 1960 to 1963, he served as the executive director of the Waterfront Commission of New York Harbor, where he prosecuted organized crime figures. He returned to legal practice in Washington, D.C. in 1963. In 1969, Ambrose was appointed as the Commissioner of Customs under President Richard M. Nixon. Under his leadership, he oversaw the implementation of Operation Intercept, which consisted in searching vehicles entering the United States from Mexico. The program was discontinued within weeks; instead, the Mexican police was expected to search for illicit drugs in cars driving into U.S. soil. Meanwhile, it was Ambrose who promoted the use of dogs to look for drugs like heroin and marijuana. In 1971, he successfully completed the seizure of 200 pounds of pure heroin entering the United States in three batches. In January 1972, he became the director of the Office of Drug Abuse Law Enforcement, a drug enforcement agency tasked primarily with the US federal government aiding local drug enforcement. He proposed the creation of the more encompassing Drug Enforcement Administration in 1973. Ambrose returned to legal practise in Washington, D.C. upon retiring from the federal government. He served on the inaugural committee of the Reagan-Bush campaign in 1980. He served as the chairman of the board of Daytop, a drug addiction treatment organization.
With his first wife, Elaine Miller, he had three sons and three daughters. After she died in 1975, he married Joan Fitzpatrick, but he later divorced. He attended Mass at St. Theresa Catholic Church in Ashburn, Virginia. He resided in Lansdowne, Virginia and later Leesburg, Virginia, where he died of a congestive heart failure at the age of 87.