James Dunn, a United States Marine who served in the Gulf War is wrongly accused of an assassination of an officer he had disputed with. Dunn is later saved from death row and recruited for a top-secret special operations squad led by Lt. Col. Grant Casey. Their mission is to neutralize criminals who had avoided conventional law enforcement methods. On his first mission, Dunn finds that his purpose is to actually be falsely perceived as the man who assassinated the first lady. Soon, a search begins for Dunn and Dr. Victoria Constantini who was a witness to what happened and had videotaped the incident. Dunn finds her and she becomes a reluctant ally to him after he saved her life after she was targeted by the conspirators and blow up her house. The military, led by General Adam Woodward, who in fact was posing as the deceased Lt. Col and is apart of the conspiracy. During the manhunt, Dunn and Constantini start to put together the pieces of who is behind the assassination which also involves Donald Bickhart, the head of his own powerful pharmacutical company behind an experimental vaccine called CRC-13 which was used to experiment on soldiers illegally which the first lady was investigating and the reason she was killed. As a smokescreen, Bickhart puts a bounty of 10 Million Dollars for anyone who can capture Dunn dead or alive. Meanwhile, Dunn finds a trustworthy ally in CIA head Ken Rackmill, who knows that Dunn is innocent and also knows that someone inside his organization is working with the conspirators who framed him in the first place. Dunn must go through Woodward himself and his henchman, Col. Alan Braddock to expose the truth before he and Victoria are killed.
Most Wanted received negative reviews from critics, as it currently holds a rating of 15% on Rotten Tomatoes based on 26 reviews. Audiences polled by CinemaScore gave the film an average grade of "C+" on an A+ to F scale. Jon Voight was nominated for a Golden Raspberry Award for Worst Supporting Actor for his performance in both this film and U Turn, but lost the trophy to Dennis Rodman for Double Team.
