Mitochondrial fission factor
Mitochondrial fission factor is a protein that in humans is encoded by the MFF gene. Its primary role is in controlling the division of mitochondria. It has also been shown to regulate peroxisome morphology.Mff is an outer mitochondrial membrane protein that binds to the GTPase Drp1; the Mff-Drp1 complex is what promotes mitochondrial fission. Knockdown of Mff causes the mitochondrial network to expand, while Mff overexpression causes it to become fragmented.
