Harris made her film debut playing a female leading role in the 1987 action film' starring Rutger Hauer. She later went to star alongside Ken Olin, Patricia Wettig, Melanie Mayron, Timothy Busfield, Peter Horton and Polly Draper in the ABC drama series Thirtysomething playing the role of Hope Murdoch Steadman. The series received critical acclaim during its run, while Harris was nominated for a Golden Globe Award for Best Actress – Television Series Drama in 1990. She directed one episode during the final season. The series ended in 1991. During that time, she also starred in the horror filmCameron's Closet and action comedy K-9 alongside Jim Belushi. In 1989, she played a real-life victim Madge Oberholtzer in the TV miniseries Cross of Fire. In 1989, Harper's Bazaar named her one of "America's 10 Most Beautiful Women". In 1990s, Harris had many leading roles in the made-for-television films and miniseries, include The Burden of Proof, Ultimate Betrayal and The Women of Spring Break. She co-starred in the 1992 psychological horror-thriller film Raising Cain, and the following year played the leading role in the thriller filmSuture. Her other notable film credits include The Pagemaster, Hangman's Curse, and The Lodger. From 1996 to 1998, she starred with Jere Burns in the NBC sitcom Something So Right. The series was canceled after two seasons. Harris has appeared in a number of television series in 2000s, including Touched by an Angel, Stargate SG-1, The West Wing, JAG, House and Criminal Minds. In 2007, she was regular cast member in the MyNetworkTV limited-run serial Saints & Sinners. At that time, she began working as writer. She was executive producer and creator of 2012 ABC drama pilot Scruples based on the 1978 novel by Judith Krantz. After six-year hiatus, in 2013 Harris returned to television appearing in the two episodes of '. In 2016, Harris starred in the first season of Hulu drama series Shut Eye, and from 2017 to 2018 had a recurring role in the Bravo comedy series Imposters. In 2020, ABC ordered a sequel for Thirtysomething and Harris set to return alongside Olin, Busfield and Wettig.
Personal life
Harris has been married six times. Her marriages include: David Silbergeld, Brian Kilcommons, photographer David Hume Kennerly , actor Cotter Smith , investment banker Michael Toomey, and current husband screenwriter and producer Bob Brush.