Chandrankunnel is a founder of the Bangalore Forum for Science and Religion. He was a founding member in 2001 of the Bangalore Initiative for Religious Dialogue, which attempts to defuse tensions between religious communities such as Hindus, Christians and Muslims. He was the Indian co-ordinator for the Science-Religion Summit in Bangalore in 2003. He organised the conference "Merging Boundaries: Mysticism, Science and Religion", inaugurated by Sri Ravi Shankar. He has worked as science editor of Deepikadaily newspaper and as its Chennai and Bangalore correspondent. A group of Indian Christians issued a letter on 1 January 2007 to various world leaders entitled A Campaign Declaration: Bangalore Initiative for Religious Dialogue . Chandrankunnel was one of the signatories. The group asserted that the 1977 ruling by India's Supreme Court that a citizen had the right to "profess, practice and propagate" ones religion does not include the right to convert another. The group called for a change to Article 18 of the Universal Declaration of Human Rights to prohibit conversion through material incentives, coercion, threats or intimidation. However, the BIRD members affirmed the Great Commission that "unequivocally calls us to witness to Christ in a pluralistic setting". Chandrankunnel was visiting professor at the University of Leuven, Faculty of Philosophy in April–May 2010. He lectured on the Physics, Philosophy and Religion of Galileo. In June 2011 he addressed a seminar on "Nation building and minority welfare", saying every citizen had a duty to bring the marginalised towards mainstream society. As of 2012 Chandrankunnel was an associate director of Geothirbhavan – Georgian CMI Centre for Counselling, Training and Transformation. He was also Director-Coordination of the Chaavara Cancer Research Institute. He was a member of the Association of Christian Philosophers of India. As of 2016 Chandrankunnel was leading annual programs for visiting students from Europe and North America on "Religions in Contemporary India". In these one-month programs the students meet representative of different religions and visit Hindu, Buddhist. Sikh, Jain, Muslim and Christian centres. On 16 December 2016, Prof. Mathew Chandrankunnel CMI took charge as the Director of Ecumenical Christian Centre and now taking new initiatives to transform and make ECC a centre of excellence, compassion and human unity by connecting it with international centres, bringing international figures to ECC and organizing international conferences along with local, national and Asian level initiatives. He is the first Catholic priest to act as the head of the centre.