Blaser obtained his undergraduate education from the University of Pennsylvania in 1969, graduated from the New York University School of Medicine in 1973, and did his post-graduate training at the University of Colorado School of Medicine from 1973 to 1979. Blaser has, since 2013, been married to fellow microbiome researcher and colleague Maria Gloria Dominguez-Bello. Two prior marriages, first to the artist and later to the writer and editor ended in divorce. Blaser was an Epidemic Intelligence Service Officer at the Centers for Disease Control and Prevention from 1979 to 1981. In 1998, Blaser established the Foundation for Bacteria, which started the . Blaser was elected the President of the Infectious Diseases Society of America in 2006 for a one-year term. He has served the National Institutes of Health on the Board of Scientific Counselors of the National Cancer Institute, and on the Advisory Board for Clinical Research. In 2011, he was elected into the National Academy of Medicine, in recognition of professional achievement and commitment to service in medicine and health. In 2014, he was the Kinyoun Lecturer at the National Institute for Allergy and Infectious Diseases at NIH, and received the Alexander Fleming Award for lifetime achievement from the Infectious Diseases Society of America. He received the Cura Personalis award from Georgetown University in 2015. His scientific papers have been cited more than 120,000 times. In 2015, he was selected to be in the TIME 100 Most Influential People in the world, He served on the Advisory Council of the National Center for Complementary and Integrative Health of the National Institutes of Health from 2015-2019. He was appointed as the Chair of the President's Advisory Council on Combating Antibiotic-Resistant Bacteria for a term from 2015–2022. Blaser sits on scientific advisory boards for Elysium Health, Procter & Gamble, Dupont, and several biotechnology start-up companies. In June 2018, Blaser joined the Scientific Advisory Board of the newly founded Seed. He is a senior advisor to the Canadian Institute for Advanced Research and a Puretech Health company Collaborator. In 2019 he received the Robert-Koch-Medal in Gold, and the Karl August Mobius Fellowship from Kiel Life Sciences.
Research
Blaser is best known for his studies of Helicobacter pylori and its relationship with human diseases. His work helped establish the role of H. pylori in the causation of gastric cancer, the second leading cause of cancer death in the world. Studies of the diversity of H. pylori lead him to identify the CagA protein and its gene in 1989, which broadened understanding of H. pylori interactions with humans. His team found that cagA+ strains induced enhanced host responses, development of atrophic gastritis, gastric cancer, and peptic ulcer disease, compared to cagA− strains, and that cagA+ strains signal human gastric cells differently from cagA− strains, and affect gastric physiology in markedly different ways than in the absence of H. pylori. This work led to a general model for the persistence of co-evolved organisms, based on the presence of a Nash equilibrium, and also for the relationship of persisting microbes to cancer, and age-related mortality. Beginning in 1996, he hypothesized that H. pylori strains might have benefit to humans as well as costs. Despite considerable and ongoing skepticism by the community of H. pylori investigators, Blaser and his colleagues progressively developed a body of research that provided evidence that gastric colonization by this organism provided protection against the esophageal diseases of GERD, Barrett's esophagus, and esophageal adenocarcinoma, work that has been confirmed by independent investigators. His work has suggested a benefit of H. pylori against such early life illnesses as childhood diarrhea and asthma. This work is consistent with the hypothesis that H. pylori is an ancient, universal inhabitant of the human stomach that has been disappearing as a result of 20th century changes in socio-economic status, including the use of antibiotics and that this loss has health consequences, not only good, but bad as well. In 1998, Blaser created the term acagia, to indicate a susceptibility for esophageal diseases in persons not carrying cagA+ H. pylori strains. Since then, acagia has come to reflect the rise in other diseases associated with the loss of cagA+ H. pylori, and may become a metaphor for the disappearance of members of the human microbiome that have symbiotic roles. In 2009, with Stanley Falkow, he hypothesized that human microecology is rapidly changing with potentially substantial consequences. He envisioned a step-wise change to explain the epidemic rise of such diseases as childhood-onset asthma and obesity. Blaser has proposed that greater understanding of our indigenous microbiota can lead to improvements in human health. He has proposed that the routine use of antibiotics in young children may be causing collateral damage, with extinctions of our ancient microbiota at critical stages of early life. This scenario may be contributing to the risk of epidemic metabolic, immunologic, and developmental disorders. Studies in mice have contributed strong support to these hypotheses., and on-going work in children with reference to many diseases, asthma, show the importance of early life microbiome perturbation in increasing risk. Recent studies provided evidence that the effects of antibiotic perturbation on the microbiota can be transmitted via the mother to the next generation, affecting both intestinal micro-ecology and disease manifestations.
''Missing Microbes''
Blaser is the author of a book for general audiences, Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues, about the degradation of internal microbial ecosystems of humans as a result of modern medical practices. Professional science writer Sandra Blakeslee helped write Missing Microbes, which was published by Henry Holt and Co. in April 2014, and has been translated into 20 languages. The book was a finalist for the 2015 LA Times Book Prize in Science, and won the National Library of China's 2017 Wenjin Book Award. Under the leadership of his wife, Maria Gloria Dominguez Bello, a group of scientists have formed the Microbiota Vault, Inc., a not-for-profit non-governmental organization public charity in the United States; Blaser serves as a member of the Board of Directors and an officer of the Foundation. Modeled after the Seed Vault in Svalbard, Norway, the Microbiota Vault has the purpose of creating a repository for the preservation of the human microbiota for future generations before it disappears, and fostering research and education about the human microbiota in developing countries.
