Ferguson, along with her husband, Theodore, founded the Los Angeles Mission on November 11, 1886. This was eventually renamed the Peniel Mission. According to Piepkorn, "The name Peniel was chosen from Genesis 32: 24-30, and is meant to connote spiritual triumph." According to Frankiel, Peniel means "Face of God". From the outset, the Peniel Mission was undenominational and nonsectarian. In 1894, the Fergusons received a significant anonymous financial donation. With this funding the Fergusons were able to plan to expand the ministry of the Peniel Mission. They invited former Methodist presiding elder Dr Phineas Bresee to join them in their endeavour, and constructed a 900-seat auditorium and ministry centre at 227 South Main Street, Los Angeles. It was decided that there would be four superintendents: Theodore and Manie Ferguson, George Studd and Phineas F. Bresee. On Sunday 21 October 1894 the 900-seat Peniel Hall was dedicated. University of Southern California president Dr. Joseph Pomeroy Widney led the 9.30am Praise Service, while Bresee preached in the 11.00am service "from the text, "And Jacob called the name of the place Peniel: for I have seen God face to face, and my life is preserved.". In the initial issue of the Peniel Herald, it was announced
Our first work is to try to reach the unchurched. The people from the homes and the street where the light from the churches does not reach, or penetrates but little. Especially to gather the poor to the cross, by bringing to bear upon them Christian sympathy and helpfulness.... It is also our work to preach and teach the gospel of full salvation; to show forth the blessed privilege of believers in Jesus Christ, to be made holy and thus perfect in love.
As Timothy Smith explains:
Here were holiness and humanitarianism working hand in hand, as in the days of Wesley. And sectarian feeling was rejected: "Peniel Mission is thoroughly evangelical but entirely undenominational," the Herald declared. Its superintendents would welcome help from all "earnest souls... who have any time over and above the work in their churches that they desire to give".
After Bresee and Widney separated from the Peniel Mission in September 1895 to form the Church of the Nazarene, Manie Ferguson provided primary leadership of the Peniel Mission. According to Schwanz,
Manie Ferguson was more outgoing than Theodore and was the guiding force for the expansion of the ministry.... Under Manie's direction, the Peniel Missions sought to provide a ministry for single women. This appears to have been a primary motivation in the growth of the movement. The women usually lived in rented rooms near the rented hall where they conducted evangelistic services. They boldly testified on street corners and in bars and houses of prostitution. All workers were unsalaried, but the local mission paid for most of their expenses. Even the Fergusons were not paid by the mission, but lived on the rental income from three small houses they owned. at www.whwomenclergy.org
According to Sandra Frankiel,
Together with his wife Manie, he offered street-corner meetings in the afternoons and evangelistic services nightly, with a meal afterwards. Their entire work, like that of most of the city holiness missions, was oriented toward soul saving and the promotion of holiness. The mission was not a church, however; converts were supposed to join one of the regular denominations. It was, rather, a holiness revival station spreading the message of Christian perfection.
"The Peniel Mission used some of the same methods as the Salvation Army, including street-corner meetings followed by parades back to the mission hall." After her husband's death in 1920, "Mother Ferguson" continued to direct the work until her own death on 8 June 1932. In 1947 the Peniel Mission became a part of the present-day World Gospel Mission. In 1998, the West Coast USA Peniel Missions experienced a significant change when the majority of Peniel Missionaries resigned from Peniel Mission and went to work for City Team Ministries leaving the Peniel Mission in Stockton, California the remaining American Peniel Mission affiliated with the WorldGospel Mission.
Poet and hymn writer
Manie Ferguson wrote many poems and hymns. The song for which she is still remembered is "Blessed Quietness" . Other hymns she wrote include: "That Man of Calvary" and "Christ in the Storm".
Writings
Echoes From Beulah. Los Angeles: T. P. & M. P. Ferguson, 1913.
Faith Tonic.
Peniel Missionary Work.
T.P. Ferguson: The Love Slave of Jesus Christ and His People and Founder of Peniel Missions. 240 pages. Includes 39 poems by Ferguson, a photo of T.P. Ferguson, biography of the life of T.P. Ferguson, notes from T.P. Ferguson's diary for 1881-1882, Bible readings and notes by T.P. Ferguson, Peniel Missionary Work, and an update of "Peniel Missionary Work".