Miller attended Swarthmore College where she received the Beik Prize for The Troubles By Our Women: The Urban Male Perspective on Independent Women in Independent Nigeria in 2005. She went on to graduate with a degree in history. After college, she moved to Brooklyn, New York where an interest in sculpture led her to answer a craigslist ad from a woodworker who was seeking an assistant. She spent her hours at the wood shop listening to the radio, and toward the end of her year working there, she heard Radiolab, which was then a local show on WNYC. She fell in love with the show and wrote them a letter, asking if she could volunteer. She started as an intern, going in one day a week to answer emails and burn CDs, and eventually became the show's first hired audio producer. After five years at Radiolab, Miller left to pursue her passion as a writer via a fellowship position at the University of Virginia where she taught and wrote fiction. Before moving to Virginia, she spent a summer cycling across the United States, a trip that she documented and featured parts of on Radiolab. After her two years at UVA, Miller returned to radio as a freelance journalist for NPR's Science Desk. On a trip to the Third Coast International Audio Festival in Chicago, she met former This American Life producer Alix Spiegel who asked Miller to produce a piece she was working on. The two began working on radio stories together and began to conceive a new long-form radio show that would become Invisibilia. Launched in January 2015, the show focuses on "the unseen forces that control human behavior." Excerpts of Invisibilia were featured on All Things Considered, Morning Edition, Radiolab and This American Life helping it to debut at #1 on the iTunespodcast chart and hold a consistent top-ten ranking in the months following its launch. In 2020, she published Why Fish Don't Exist, a personal memoir incorporating the life and work of David Starr Jordan.
Personal life
Miller openly admits to being an ophidiophobe. She is married to Grace Miller and they have a son.