The Cleveland Indians chose Chisenhall with the 29th overall pick in the 2008 MLB draft. He played 68 games in 2008 for the Indians Class A Short Season Affiliate the Mahoning Valley Scrappers posting a.290 AVG with 5 HR and 45 RBI. In 2009 and 2010, he played with the AA Akron Aeros. On June 27, 2011, Chisenhall was promoted from the Class AAAColumbus Clippers, and went 2-for-4 in his major league debut against the Arizona Diamondbacks. On July 6, 2011 Chisenhall hit his first major league home run off of Boone Logan of the New York Yankees. On July 7, 2011, Chisenhall was hit with a fastball thrown by Toronto Blue Jays pitcher Carlos Villanueva and had to leave the game with facial contusions. In 2012, he finished with a.260 batting average, 12 home runs, and 38 runs batted in. On May 13, 2013, Chisenhall was sent down to the Class AAA Columbus Clippers. He was recalled on May 18. On June 9, 2014, Chisenhall became the first player in MLB history to have 5 hits, 3 home runs, and 9 RBI in 5 plate appearances. He is no longer the only such player. On June 6, 2017, Scooter Gennett had a better performance with 5 hits, 4 home runs, and 10 RBI in 5 plate appearances. In 2015, Chisenhall started out as the Indians everyday third baseman. On June 10, after poor offensive output, Lonnie was again optioned to Cleveland's Class AAA Columbus Clippers. Giovanny Urshela was called on to play third base for the Indians. While in Columbus, Chisenhall transitioned to right field. On July 29, Chisenhall was recalled back on the Indians roster. Called on as a full-time right fielder, his transition has been deemed a success by many. In Game 2 of the 2017 American League Division Series, with the Indians down 8-3 in the 6th inning with two outs and runners on 2nd and 3rd against the Yankees and the count 0-2 on Chisenhall, Yankees reliever Chad Green threw an inside pitch that grazed the bottom of Chisenhall's bat. The home plate umpire called it a hit by pitch, awarding Chisenhall 1st base and bringing up Indians slugger Francisco Lindor with the bases loaded. Replay showed that the ball did not actually hit Chisenhall, but Yankees manager Joe Girardi decided not to challenge the call. On the second pitch he saw, Lindor hit a grand slam to right field, bringing the Indians within a run. The Indians would go on to tie the game in the 8th and walk off in the 13th. He began the 2018 season on the disabled list and was activated on June 5, 2018. He was placed back on the disabled list less than a month later. Chisenhall became a free agent following the 2018 season.
Pittsburgh Pirates
On November 27, 2018, Chisenhall signed a one-year contract with the Pittsburgh Pirates worth $2.75 million. He was placed on the injured list at the end of Spring training after sustaining an injury to his finger. He never played a game for the Pirates. On February 21, 2020, Chisenhall announced his retirement from professional baseball.
Personal life
Chisenhall and his wife, Meredith, have three children. Their first child, a son named Cutter, was born in 2012. Their second child, a son named Cannon, arrived in April 2014. Their third child, a daughter named Loftin, was born in August 2017.
