After completing her PhD, Sockett worked as a postdoctoral research associate at the University of Illinois at Urbana–Champaign and then the University of Oxford. In 1991, she was appointed as a Lecturer at the University of Nottingham and subsequently promoted to senior lecturer in 2001, Reader in 2004 and Professor in 2005. Her research group started by studying the photosynthetic bacterium Rhodobacter sphaeroides. Her interests in bacterial physiology and mechanisms then turned to understanding the bacterial predatorBdellovibrio bacteriovorus. Bdellovibrio preys upon a wide range of bacteria including antibiotic-resistant pathogens that are harmful to human health. Sockett's lab have studied the genome of Bdellovibrio during the invasion of other bacteria. Her group has identified several Bdellovibrio genes that make enzymes which break down important structural components of bacteria, and also secrete enzymes that break down chromosomes. She is studying the application of predatory bacteria like Bdellovibrio to treat antimicrobial-resistant infections. Sockett's group worked together with Alexandra Willis and her PhD supervisor at Imperial College London to study Bdellovibrio predation in a zebrafish infection model. Zebrafish infected with a lethal dose of the antibiotic-resistant human pathogen Shigella flexneri were given Bdellovibrio as a treatment. Together, the researchers showed that Bdellovibrio could kill the Shigella, working synergistically with the zebrafishs' own immune system to promote zebrafish survival. Sockett and her group collaborated with Erkin Kuru at Indiana University Bloomington, using fluorescent D-amino acids to illuminate the mechanisms by which Bdellovibrio invades its prey. They discovered that Bdellovibrio forms a small reinforced 'porthole' in the cell wall of its prey through which it squeezes and then re-seals from the inside. She also has long-standing collaborations with Andrew Lovering at the University of Birmingham, who studies the structural biology of predatory Bdellovibrio enzymes, and Waldemar Vollmer at Newcastle University, who studies the structure of bacterial cell walls. As part of a Human Frontier Science Program grant, Sockett collaborated with Shin-Ichi Aizawa to study the Bdellovibrio interaction with Escherichia coli. Her strains appeared in electron microscope images in the 2013 book The Flagellar World. Her research has been funded by the Biotechnology and Biological Sciences Research Council, Engineering and Physical Sciences Research Council, Medical Research Council, Leverhulme Trust and the Wellcome Trust. Sockett is a communicator and role model for careers in microbiology, which was recognised by the award of the Peter Wildy prize of the Society for General Microbiology in 2006, where her prize lecture was entitled Not Just Germs - Bringing Bacteria to Life. Socket is an advocate for public engagement and science outreach.
Awards and honours
Sockett was interviewed on The Life Scientific by Jim Al-Khalili in 2017. Other awards and honours include:
