On August 13, 2010, she made her Strikeforce debut at in a reserve bout for their one-night Women's Welterweight tournament. She defeated Colleen Schneider via unanimous decision after two rounds. Carmouche returned to the promotion at Strikeforce Challengers 12 on November 19, 2010, where she defeated Jan Finney via TKO in the third round. On February 23, 2011, it was announced that number one title contender Miesha Tate had suffered a knee injury and that Carmouche would step in on short notice to face Women's Bantamweight champion Marloes Coenen on March 5, 2011 at. Carmouche was defeated via triangle choke in the fourth round, after dominating two of the previous rounds. On July 22, 2011, Carmouche faced Sarah Kaufman at Strikeforce Challengers: Voelker vs. Bowling III in Las Vegas, Nevada. She was defeated by unanimous decision. Carmouche was scheduled to return to Strikeforce to face Sara McMann at on November 3, 2012, but the event was cancelled.
Carmouche faced Ashleigh Curry at Invicta Fighting Championships 1 on April 28, 2012. She won the fight via TKO in the first round. Carmouche faced Kaitlin Young at Invicta Fighting Championships 2 on July 28, 2012. She won the fight via submission due to a rear-naked choke in the second round.
Ultimate Fighting Championship
It was announced at the pre-fight press conference by UFC President Dana White that former Strikeforce Women's Bantamweight Champion Ronda Rousey would be the very first UFC Women's Bantamweight Champion. It was confirmed by White that Carmouche would be challenging Rousey for the Women's Bantamweight title at UFC 157. In the early part of the first round, Carmouche locked in a standing rear-naked choke/face crank on Rousey. However, Rousey escaped and eventually finished the fight by armbar with 11 seconds left in the first round. Carmouche was expected to face Miesha Tate at UFC on Fox 8 on July 27, 2013. However, Tate was pulled from the bout to participate as a coach on The Ultimate Fighter 18. Carmouche instead faced promotional newcomer Jéssica Andrade. She won the fight by TKO in round two, earning her first win inside the Octagon. In her third UFC fight, Carmouche faced Alexis Davis on November 6, 2013 at UFC Fight Night 31. She lost the fight via unanimous decision. Carmouche faced Miesha Tate in the co-main event at UFC on Fox 11. She lost the back-and-forth fight via unanimous decision. Carmouche faced Lauren Murphy on April 4, 2015 at UFC Fight Night 63. She won the fight by unanimous decision. Carmouche faced Katlyn Chookagian on November 12, 2016 at UFC 205. She won the fight via split decision. Carmouche faced Alexis Davis in a women's flyweight bout on December 9, 2017 at UFC Fight Night 123. She lost the fight by split decision. Carmouche faced Jennifer Maia on July 14, 2018 at UFC Fight Night 133. She won the fight by unanimous decision. Carmouche faced Lucie Pudilová on February 23, 2019 at UFC on ESPN+ 3. She won the fight by unanimous decision. A rematch with Valentina Shevchenko was scheduled on August 10, 2019 at UFC on ESPN+ 14 for the UFC Women's Flyweight Championship. She lost the fight via unanimous decision. On December 6, 2019, it was announced that Carmouche had been released from the UFC despite signing a new contract after the failed title bid.
Bellator MMA
After less than three weeks Carmouche was released from UFC, she was signed by Bellator MMA. Carmouche is scheduled to make her debut at Bellator against Mandy Bohm on May 29, 2020 at Bellator 243.
Championships and accomplishments
2010 – WMMA Press Awards Newcomer of the Year
Personal life
Carmouche is openly lesbian, and has a daughter with her wife. She has a tattoo on her left side representing the Chinese zodiac symbol of her mother and sister. Carmouche is the spokesperson for Medical Marijuana Inc. on the cannabidiol therapeutic benefits for athletes.