List of number-one dance airplay hits of 2010 (U.S.)
These are the Billboard magazine Hot Dance Airplay number one hits of 2010.
Note that Billboard publishes charts with an issue date approximately 7–10 days in advance.
| Issue date | Song | Artist | Remixer | Source |
| January 2 | "Hang On" | Plumb | Dave Audé, Digital Dog, Bronleewe & Bose | |
| January 9 | "Hot" | Inna | Play & Win | |
| January 16 | "Tik Tok" | Kesha | Fred Falke | |
| January 23 | "Tik Tok" | Kesha | Fred Falke | |
| January 30 | "Hot" | Inna | ||
| February 6 | "Tik Tok" | Kesha | Fred Falke | |
| February 13 | "Tik Tok" | Kesha | Fred Falke | |
| February 20 | "Tik Tok" | Kesha | Fred Falke | |
| February 27 | "Bad Romance" | Lady Gaga | Hercules & Love Affair, Dave Audé, Kaskade, Bimbo Jones, Starsmith, Richard Vission, DJ Dan, Skrillex, Grum, Chew Fu | |
| March 6 | "Secret Love" | Kim Sozzi | Josh Harris, Wendel Kos, Stellar Project | |
| March 13 | "Love Keeps Calling" | AnnaGrace | Basto, Lucky Charmes & Tony Verdult | |
| March 20 | "Love Keeps Calling" | AnnaGrace | Basto, Lucky Charmes & Tony Verdult | |
| March 27 | "Love Keeps Calling" | AnnaGrace | Basto, Lucky Charmes & Tony Verdult | |
| April 3 | "Secret Love" | Kim Sozzi | ||
| April 10 | "Heartbreak" | M'Black | Felix Baumgartner, Ron May, Inner Smile, Caged Baby | |
| April 17 | "Heartbreak" | M'Black | Felix Baumgartner, Ron May, Inner Smile, Caged Baby | |
| April 24 | "Sweet Disposition" | The Temper Trap | Axwell, Dirty South | |
| May 1 | "Rude Boy" | Rihanna | Wideboys, Jonathan Peters, Chew Fu, Low Sunday | |
| May 8 | "Break Your Heart" | Taio Cruz featuring Ludacris | Paul Thomas, Vito Benito | |
| May 15 | "Ghosts N Stuff" | Deadmau5 featuring Rob Swire | ||
| May 22 | "Heartbreak on Vinyl" | Blake Lewis | Bimbo Jones, LA Riots, Chew Fu | |
| May 29 | "Naturally" | Selena Gomez & the Scene | Dave Audé, Ralphi Rosario, Disco Fries | |
| June 5 | "Stereo Love" | Edward Maya & Vika Jigulina | Molella, DaBo | |
| June 12 | "Happiness" | Alexis Jordan | Wideboys, Jump Smokers | |
| June 19 | "Gettin' Over You" | David Guetta & Chris Willis Featuring Fergie & LMFAO | ||
| June 26 | "Stereo Love" | Edward Maya & Vika Jigulina | ||
| July 3 | "Gettin' Over You" | David Guetta & Chris Willis Featuring Fergie & LMFAO | ||
| July 10 | "California Gurls" | Katy Perry Featuring Snoop Dogg | ||
| July 17 | "California Gurls" | Katy Perry Featuring Snoop Dogg | ||
| July 24 | "California Gurls" | Katy Perry Featuring Snoop Dogg | ||
| July 31 | "Cooler Than Me" | Mike Posner | Gigamesh | |
| August 7 | "Dynasty" | Kaskade Featuring Haley | Michael Woods, Dada Life, Ryan Marciano & Sunnery James | |
| August 14 | "Better Than Her" | Matisse | ||
| August 21 | "Dynamite" | Taio Cruz | Mixin' Marc, Stonebridge, Ralphi Rosario | |
| August 28 | "The Radio" | Get Far Featuring H-Boogie | ||
| September 4 | "The Radio" | Get Far Featuring H-Boogie | ||
| September 11 | "We No Speak Americano" | Yolanda Be Cool & DCUP | ||
| September 18 | "Stereo Love" | Edward Maya & Vika Jigulina | ||
| September 25 | "Stereo Love" | Edward Maya & Vika Jigulina | ||
| October 2 | "Teenage Dream" | Katy Perry | Kaskade | |
| October 9 | "Teenage Dream" | Katy Perry | Kaskade | |
| October 16 | "I'm in Love " | Alex Gaudino | ||
| October 23 | "I'm in Love " | Alex Gaudino | ||
| October 30 | "Only Girl " | Rihanna | Bimbo Jones, Rosabel, Mixin Marc & Tony Svejda, CCW | |
| November 6 | "Only Girl " | Rihanna | Bimbo Jones, Rosabel, Mixin Marc & Tony Svejda, CCW | |
| November 13 | "I'm in Love " | Alex Gaudino | ||
| November 20 | "Take Over Control" | Afrojack featuring Eva Simons | ||
| November 27 | "Somewhere" | DJ Mog featuring Sarah Lynn | ||
| December 4 | "Raise Your Glass" | Pink | Laidback Luke, Bimbo Jones | |
| December 11 | "Only Girl " | Rihanna | ||
| December 18 | "Take Over Control" | Afrojack featuring Eva Simons | ||
| December 25 | "Raise Your Glass" | Pink |