List of National Football League career interceptions leaders
This is the list of National Football League players, who have recorded at least 50 interceptions.
| Bold denotes an active player | Elected into the Pro Football Hall of Fame |
| Rank | Pos. | Player | Seasons by team | Total interceptions | Year of induction into Pro Football Hall of Fame | Ref. |
| 1 | FS | Paul Krause | Washington Redskins Minnesota Vikings | 81 | 1998 | |
| 2 | DB | Emlen Tunnell | New York Giants Green Bay Packers | 79 | 1967 | |
| 3 | FS | Rod Woodson | Pittsburgh Steelers San Francisco 49ers Baltimore Ravens Oakland Raiders | 71 | 2009 | |
| 4 | DB | Dick "Night Train" Lane | Los Angeles Rams Chicago Cardinals Detroit Lions | 68 | 1974 | |
| 5 | DB | Ken Riley | Cincinnati Bengals | 65 | — | |
| 5 | DB | Charles Woodson | Oakland Raiders Green Bay Packers | 65 | Eligible in 2021 | |
| 7 | FS | Ed Reed | Baltimore Ravens Houston Texans New York Jets | 64 | 2019 | |
| 8 | S | Ronnie Lott | San Francisco 49ers Los Angeles Raiders New York Jets | 63 | 2000 | |
| 8 | FS | Darren Sharper | Green Bay Packers Minnesota Vikings New Orleans Saints | 63 | — | |
| 10 | CB | Pittsburgh Steelers Seattle Seahawks Green Bay Packers | 62 | - | ||
| 10 | DB | Dick LeBeau | Detroit Lions | 62 | 2010 | |
| 12 | DB | Emmitt Thomas | Kansas City Chiefs | 58 | 2008 | |
| 13 | DB | Everson Walls | Dallas Cowboys New York Giants Cleveland Browns | 57 | — | |
| 13 | DB | Johnny Robinson | Dallas Texans / Kansas City Chiefs | 57 | 2019 | |
| 13 | FS | Eugene Robinson | Seattle Seahawks Green Bay Packers Atlanta Falcons Carolina Panthers | 57 | — | |
| 13 | DB | Bobby Boyd | Baltimore Colts | 57 | — | |
| 13 | DB | Mel Blount | Pittsburgh Steelers | 57 | 1989 | |
| 18 | DB | Lem Barney | Detroit Lions | 56 | 1992 | |
| 18 | DB | Pat Fischer | St. Louis Cardinals Washington Redskins | 56 | — | |
| 20 | FS | Aeneas Williams | Phoenix / Arizona Cardinals St. Louis Rams | 55 | 2014 | |
| 21 | DB | Darrell Green | Washington Redskins | 54 | 2008 | |
| 21 | DB | Willie Brown | Denver Broncos Oakland Raiders | 54 | 1984 | |
| 21 | CB | Eric Allen | Philadelphia Eagles New Orleans Saints Oakland Raiders | 54 | — | |
| 24 | CB | Ty Law | New England Patriots New York Jets Kansas City Chiefs Denver Broncos | 53 | 2019 | |
| 24 | CB | Deion Sanders | Atlanta Falcons San Francisco 49ers Dallas Cowboys Washington Redskins Baltimore Ravens | 53 | 2011 | |
| 26 | CB | Champ Bailey | Washington Redskins Denver Broncos | 52 | 2019 | |
| 26 | DB | Jack Butler | Pittsburgh Steelers | 52 | 2012 | |
| 26 | DB | Bobby Dillon | Green Bay Packers | 52 | 2020 | |
| 26 | DB | Jimmy Patton | New York Giants | 52 | — | |
| 26 | DB | Mel Renfro | Dallas Cowboys | 52 | 1996 | |
| 26 | DB | Larry Wilson | St. Louis Cardinals | 52 | 1978 | |
| 32 | DB | Donnie Shell | Pittsburgh Steelers | 51 | 2020 | |
| 32 | CB | Asante Samuel | New England Patriots Philadelphia Eagles Atlanta Falcons | 51 | — | |
| 32 | DB | Bobby Bryant | Minnesota Vikings | 51 | — | |
| 35 | DB | Terrell Buckley | Green Bay Packers Miami Dolphins Denver Broncos New England Patriots New York Jets New York Giants | 50 | — | |
| 35 | DB | Don Burroughs | Los Angeles Rams Philadelphia Eagles | 50 | — | |
| 35 | FS | Deron Cherry | Kansas City Chiefs | 50 | — | |
| 35 | DB | John Harris | Seattle Seahawks Minnesota Vikings | 50 | — | |
| 35 | DB | Yale Lary | Detroit Lions | 50 | 1979 |