| Rank | Title | Studio | Actor | Director | Gross |
| 1. | Avatar | 20th Century Fox | Sam Worthington, Zoe Saldana, Stephen Lang, Michelle Rodriguez and Sigourney Weaver | James Cameron | $466,141,929 |
| 2. | Toy Story 3 | Walt Disney Studios | voices of Tom Hanks, Tim Allen, Joan Cusack, Don Rickles, Wallace Shawn, John Ratzenberger, Estelle Harris, Blake Clark, Jeff Pidgeon, Ned Beatty, Michael Keaton, Jodi Benson and John Morris | Lee Unkrich | $410,171,027 |
| 3. | Alice in Wonderland | Walt Disney Studios | Johnny Depp, Anne Hathaway, Helena Bonham Carter, Crispin Glover, Matt Lucas, Mia Wasikowska, Alan Rickman, Stephen Fry, Michael Sheen and Timothy Spall | Tim Burton | $332,430,200 |
| 4. | Iron Man 2 | Paramount Pictures | Robert Downey Jr., Gwyneth Paltrow, Don Cheadle, Scarlett Johansson, Sam Rockwell, Mickey Rourke and Samuel L. Jackson | Jon Favreau | $312,433,331 |
| 5. | ' | Summit Entertainment | Kristen Stewart, Robert Pattinson, Taylor Lautner, Bryce Dallas Howard, Billy Burke and Dakota Fanning | David Slade | $300,531,751 |
| 6. | Inception | Warner Bros. Pictures | Leonardo DiCaprio, Ken Watanabe, Joseph Gordon-Levitt, Marion Cotillard, Ellen Page, Tom Hardy, Cillian Murphy, Tom Berenger and Michael Caine | Christopher Nolan | $292,558,188 |
| 7. | Harry Potter and the Deathly Hallows – Part 1 | Warner Bros. Pictures | Daniel Radcliffe, Rupert Grint, Emma Watson, Helena Bonham Carter, Robbie Coltrane, Ralph Fiennes, Michael Gambon, Brendan Gleeson, Richard Griffiths, John Hurt, Rhys Ifans, Jason Isaacs, Alan Rickman, Fiona Shaw, Timothy Spall, Imelda Staunton and David Thewlis | David Yates | $280,230,127 |
| 8. | Despicable Me | Universal Pictures | voices of Steve Carell, Jason Segel, Russell Brand, Kristen Wiig, Miranda Cosgrove, Will Arnett and Julie Andrews | Pierre Coffin and Chris Renaud | $251,083,040 |
| 9. | Shrek Forever After | Paramount Pictures | voices of Mike Myers, Eddie Murphy, Cameron Diaz, Antonio Banderas, Julie Andrews, John Cleese and Walt Dohrn | Mike Mitchell | $238,736,787 |
| 10. | How to Train Your Dragon | Paramount Pictures | voices of Jay Baruchel, Gerard Butler, Craig Ferguson, America Ferrera, Jonah Hill, Christopher Mintz-Plasse, T.J. Miller and Kristen Wiig | Chris Sanders and Dean DeBlois | $217,581,231''' |
