The Lepenac springs out on the Kodža Balkan mountain, east of the city of Prizren, Kosovo, at an altitude of. It flows eastward, into the župa of Sirinić, between the Žar mountainfrom the north and alongside the northern slopes of the Šar Mountainsfrom the south. From the Šar Mountains it receives many small tributaries, most notably the Suva reka, as it passes next to the villages of Sevce and Jazhincë, the ski resort of Brezovica and a small town and regional center of Štrpce. The Lepenac continues between the Šar Mountains from the south and Nerodimka mountain from the north, next to the villages of Biti e Poshtëme, Gotovushë, Brod and Doganaj, where the river makes an elbow turn to the south entering the Kosovo field.
For several kilometers the Lepenac flows parallel to the Nerodimka river, flows next to the villages of Kovaçefc and Bob, and receives its major tributary the Nerodimka from the left at the town of Kaçanik, at the beginning of the Kaçanik Gorge. The gorge, as the narrowest part of the Lepenac river valley, is located between the Sharr Mountains on the west and Skopska Crna Gora on the east and connects the Kosovo field and Skopje depressions. The gorge is long, carved in the limestone and slate terrain. Higher parts of the gorge are actually formed by the ancient outflow of the now extinct lake. The village of Pustenik and small town of Hani I Elezit are located in the gorge. After Hani i Elezit, the Lepenac becomes a border river between Kosovo and Macedonia, before it leaves the gorge after the village of Seçishtë and leaves Kosovo after the course of.
Skopje depression
For the remaining, the Lepenac flows through the low Skopje depression, part of the composite valley of the river Vardar. Immediately entering the Greater Skopje area, it receives several small streams from the left, from the Skopska Crna Gora mountain. It passes next to the ruins of the ancient city of Scupi, but has no major settlements on its Macedonian course, before it reaches the northern suburbs of Skopje, Bardovci and Novo Selo, and empties into the Vardar at the Skopje's northern borough of Gjorče Petrov at an altitude of.
Characteristics
The Lepenac belongs to the Aegean Seadrainage basin, with its own drainage area of . It is not navigable. The Kačanik gorge is a route for the both road and railway Kraljevo-Priština-Skopje. The river has a potential for hydroelectrical production, but even though being a part of the former Ibar-Lepenac Hydrosystem project, it is not much used, either for energy production or irrigation. The Lepenac was a part of the artificial bifurcation, as the Nerodimka connected both Lepenac and Sitnica rivers via a canal, thus connecting Aegean and Black Seadrainage basins, but the canal was covered after World War II.
