Afterwards, the XI was sent to the Balkans, where it seems to have stayed for a century or so. The location of its base is uncertain prior to 9 CE, when it is recorded at Burnum on the coast with Legio VII Claudia, mostly involved in construction and development works such as roads. Vexillationes were stationed at Salona and Gardun as well. In 42 AD, Legio XI was still stationed at Burnum when the governor of Dalmatia, Scribonianus, revolted against Claudius. In response, Legio XI put down the rebellion and was awarded the title Claudia Pia Fidelis. Legio XI Claudia remained at Burnum until around 68 AD, at the time of the death of Nero. During the Year of the Four Emperors, Legio XI Claudia, alongside Legio VII Claudia and Legio XIIII Gemina, sided with Otho, who had executed Galba against Vitellius. They marched to the Battle of Bedriacum but arrived too late, and Vitellius ordered Legio XI Claudia to return to the Balkans without any punishment. Legio XI then sided with Vespasian and participated in the Second Battle of Bedriacum, which resulted in a victory for Vespasian and his accession as emperor. In 70 AD, Legio XI was part of the expeditionary force under Cerialis to put down the Batavian Revolt on the Rhine. They were then stationed at Vindonissa in 71 AD. There are reports of Legio XI fighting in on the Rhine in 73–74 AD and they participated in Domitian's war against the Chatti in 83 AD. It is believed to have been stationed in Mainz at the time. Later in 101, it was sent to Brigetio in Pannonia. They participated in Trajan's Dacian Wars from 101–106 AD, commemorated with a column in Rome. Legio XI Claudia was then sent to Durostorum before 114 AD, when they are first attested at the site, and would remain headquartered there for at least the next three centuries. Soldiers of Legio XI Claudia were dispatched to occupy the Crimea, build the fortress at Draschna in Buzau, and to serve bureaucratic functions in Tomis. A vexillatio was sent to Judea in 132 under Hadrian to suppress the Bar Kokhba revolt; an inscription bearing the legion's name was found near Betar. In 193, Legio XI Claudia supported Septimus Severus and they fought against Pescennius Niger, besieging Byzantium, forcing their way through the Cilician gates, and fighting against his forces at the Battle of Issus. They also took part in Severus' Parthian campaign, in which they helped capture Ctesiphon in 198.
In 260–268 the Legion supported Gallienus in his war against Postumus of the Gallic Empire, being awarded the title Pia Fidelis for the 5th and 6th times, although unlike other units it never received a 7th recognition. In 273 the Legion participated in road construction in modern Jordan, and in 295 a detachment was present in Egypt. In 298 a detachment of XI Claudia was stationed in Mauretania.Two Christians within the legion named Julius and Hesychius were persecuted by Diocletian in 302, at Durostorum. Aurelius Sudecentius, a soldier of Legio XI Claudia's western detachment, died in Mauretania and was commemorated by a tombstone in Aquileia dating to the 4th century AD. In 395–425, the Legion remained headquartered on the Danube at Durostorum, with field army detachments under the Magister Militum per Gallias and under the Magister Militum Praesentalis II.