The Universe is under threat by a demonic cult led by Tongtian Jiaozhu. The Jade Emperor, the supreme ruler of Heaven, orders Immortal Donghua to find seven other worthy beings and form a team known as the Eight Immortals to counter the cult. After the first five members – Tieguai Li, Han Zhongli, Zhang Guolao, Lan Caihe and He Xiangu – have joined, Donghua chooses to undergo reincarnation to help the remaining two members – Han Xiangzi and Cao Guojiu – achieve immortality faster. He is reincarnated as Lü Dongbin and serves as the team leader. However, he has to overcome his romantic entanglements with Peony Fairy because romance between immortals is forbidden by Heaven's laws. At one point, Tongtian Jiaozhu implants a "blood curse" in Lü Dongbin which causes the latter to lose control of his senses and go rogue. Tongtian Jiaozhu is later betrayed and killed by his treacherous follower, Pangolin, who absorbs his powers. Pangolin, who has a crush on He Xiangu, cleverly manipulates the Eight Immortals and causes them to turn against each other and sow discord between them and other deities. The Eight Immortals combine their strengths to defeat Pangolin and the evil forces and bring peace to the Universe.
Cast
;Eight Immortals
Steve Ma as Lü Dongbin, the leader of the Eight Immortals.
* Ma also portrayed Immortal Donghua, Lü Dongbin's previous avatar. He voluntarily undergoes reincarnation into the human world to find the remaining immortals-to-be and help them attain immortality faster.
* Chang also portrayed Fei Zhangfang, Han Xiangzi's previous avatar. He was very filial to his mother but extremely impulsive and stubborn.
Deborah Sim as Lan Caihe, a street performer who becomes an immortal with Sun Wukong's help. He was the Barefoot Immortal in his previous life.
Ling Xiao as Zhang Guolao, an eccentric Taoist who becomes an immortal after consuming rare herbs.
Lin Yisheng as Tieguai Li, an apprentice of Taishang Laojun and the first to join the team.
Mak Hiu-wai as Han Zhongli, a former Han dynasty general who becomes an immortal with Donghua's help.
* Hong Junrui as the Cowherd Boy, Han Zhongli's previous avatar. He was sent to be reincarnated into the human world as punishment after carelessly allowing Taishang Laojun's divine bull to escape and cause trouble.
Li Haijie as Cao Guojiu, the maternal uncle of a Song dynasty emperor and the last to join the team.
;Others
Phyllis Quek as Bai Mudan, a maiden whom Lü Dongbin is destined to have romantic entanglements with. She becomes an obstacle to his quest to unite the Eight Immortals because he is forced to choose between his romance with her and his allegiance to his team.
* Quek also portrayed Peony Fairy, Bai Mudan's previous avatar. She has a crush on Immortal Donghua and was banished to the human world for breaking Heaven's laws.
Yvonne Lim as Long San, the Dragon King's third daughter who is revealed later to be actually an offspring of the Evil Dragon and Chunying. She has a crush on Han Xiangzi and transforms herself to look like Zhenniang.
* Lim also portrayed Zhenniang, Fei Zhangfang's mute but virtuous wife.
Xie Shaoguang as Pangolin, a treacherous demon who has a crush on He Xiangu. He betrays Tongtian Jiaozhu, absorbs his powers, and commit several atrocities in his attempt to destroy Lü Dongbin and the other Immortals and have He Xiangu for himself.
Hong Huifang as Chunying, the widow of the Evil Dragon and Long San's mother. She used to be one of Tongtian Jiaozhu's deputies and committed several wicked deeds in her bid to kill Lü Dongbin and avenge her husband. However, she repents after she is touched by her daughter's filial piety and returns to the path of goodness.
Tracer Wong as Tree Demoness, one of Tongtian Jiaozhu's deputies. She has an affair with Pangolin.
Huang Shinan as Tongtian Jiaozhu, Taishang Laojun's evil junior who formed a demonic cult to challenge Heaven.
Vincent Ng as Sun Wukong, the protagonist in Journey to the West who is now known as the "Fighting Victorious Buddha" after completing the quest to obtain the Buddhist scriptures. He is a friend and ally of the Eight Immortals.
* Ng also portrayed Sun Ying, the Six Eared Macaque's son and Sun Wukong's apprentice. He has a crush on Long San and relentlessly tries to win her heart.
Ding Lan as Guanyin, the Bodhisattva of compassion and mercy. She shows up to help the Immortals when they are in desperate situations.
Yang Dawei as Jade Emperor, the supreme ruler and patriarch of Heaven.
