Zadoc-Kahn was born on 2 September 1870, in the 3rd arrondissement of Paris. He was one of six children of Ernestine Meyer and Zadoc Kahn, the Chief Rabbi of France; his sisters were Hélène, Anne and Berthe; his brothers were Paul and Edmond. He began a medical career as an intern in Paris hospitals from 1892. He qualified as a medical doctor in 1897. In 1899, he married Suzanne Esther Lang, who was born on 26 March 1876 in Paris to Fleurette Silz Lang and Ernest Lang, a textile manufacturer. He is recorded on his marriage certificate as being a doctor at Hôtel-Dieu de Paris. They had three children, Bertrand, Jacqueline and Jean. In 1914, he became the Chief Medical Officer of the Rothschild Hospital and remained in that role until his murder. He was a board member and assistant treasurer of the Curie Foundation in 1924, and later treasurer. In 1915, during World War I, he travelled as a military doctor aboard the hospital ship, the Sphinx, as part of the Allied Powers' expedition to Salonika, to rally the large Jewish population of the city to the Allied cause, to help the beleaguered troops; this resulted in the creation of the Macedonian front. He had the rank of major in 1918 and was awarded the Croix de Guerre and the Cross of the Order of St. Sava. In 1923, his wife Suzanne co-founded the Jewish Women's Union for Palestine with feminist advocateYvonne Netter; the Union later became the French section of the Women's International Zionist Organization. In 1925, he became one of the eight-member editorial board of :fr:La Revue juive|La Revue juive - a short-lived journal begun by Albert Cohen, the aim of which was to be at the political centre of the perceived contemporary Jewish renaissance; - other members included Albert Einstein, Sigmund Freud, Georg Brandes and Charles Gide. Upon the defeat of France to Nazi forces in 1940, Zadoc-Kahn's son, Bertrand, a cardiologist at the American Hospital of Paris shot himself in despair. Katharine Graham, owner of The Washington Post, wrote how her father, Eugene Meyer, the American financier and cousin of Zadoc-Kahn who had lived with him for six months, offered to resettle his family to the U.S.A. as he had with others. Zadoc-Kahn and his wife were too devastated at their son's suicide and declined the offer. The couple went into hiding in a village on the outskirts of Paris; their daughter, Jacqueline, was hidden by a catholic family. Annette Benacerraf, Zadoc-Kahn's grand-niece, related to her husband how one of his last known addresses in France was in Le Ruel, Haravilliers in Seine-et-Oise, north-west of Paris and from here a letter was sent by Zadoc-Kahn to Désirée Damengout, a nursing colleague at the Rothschild Hospital, containing the following: "I beg you to convey my wishes to all my friends on Santerre Street, nurses and doctors. If you have the time, I will be very happy to hear from you and all of you." The couple was discovered in a house at Marines, Seine et Oise, on 1 November 1943 by the French gendarmérie and taken away. They were transported on Convoy No. 62, on 20 November, from Le Camp de Drancy to Auschwitz . They were killed on their arrival at Auschwitz on 23 November. Meyer found out about their arrest and disappearance from Adolphe Dreyfus in New York in the spring of 1944. He kept a portrait of Zadoc-Kahn in his New York home. Jacqueline Zadoc-Kahn survived the war.