Raised in the Flint, Michigan, area, Kuzma is the son of Karri Kuzma, a high school shot put champion who attended college on a track scholarship. He has a younger half-brother named Andre and a younger half-sister named Briana. Kuzma is biracial. Kuzma met his father only once as an infant, but viewed the father of his half-siblings, Larry Smith, as a father figure. Karri Kuzma and Smith put a toy basketball rim in the living room for Kyle when he was only two years old, thus igniting his passion for basketball. Kuzma has described Flint as "'a really violent place there's a lot of temptation to get into the streets.'" However, Kuzma described basketball as his "'safe haven'". Kuzma attended Swartz Creek Community Schools and transferred to Bentley High School in Michigan, where he averaged 17.9 points, 14.4 rebounds, 3.8 assists and 3.4 blocks per game as a junior. Kuzma sent tapes of his shooting at the YMCA to preparatory schools; Vin Sparacio, head coach at Rise Academy in Philadelphia, saw a 6'6", 175-pound, raw player who had a great feel for the game, and immediately brought him in. As a high school senior at Rise Academy, Kuzma averaged 22 points and seven rebounds per game. Kuzma received offers to play with Division I schools including Connecticut, Iowa State, Tennessee, and Missouri, among others, before deciding on the University of Utah.
College career
Kuzma enrolled at the University of Utah in 2013. He redshirted his freshman year due to the fact that he signed late. He became a starter for the Utes in his sophomore year, when he averaged 10.8 points per game. As a junior in 2016–17, he averaged 16.4 points, 9.3 rebounds, and 2.4 assists per game, which earned him first-team All-Pac-12 honors. After the season, Kuzma decided to enter the 2017 NBA draft, foregoing his final year of college basketball eligibility. Kuzma graduated from the University of Utah with a degree in sociology.
Kuzma was selected with the 27th overall pick in the 2017 NBA draft by the Brooklyn Nets. In a draft-day trade, he was dealt along with Brook Lopez to the Los Angeles Lakers in exchange for D'Angelo Russell and Timofey Mozgov. Prior to the draft, Kuzma had been projected to go in the second round. On July 3, 2017, he signed his rookie scale contract with the Lakers. During the seven out of eight games he played for the Lakers in the 2017 NBA Summer League, Kuzma led the team in points scored and became a consistent presence during the event. He recorded averages of 21.9 points, 6.4 rebounds, 2.7 assists, 1.4 blocks, and 1.1 steals per game and was named to the All-Summer League Second Team that year. He was also named the Summer League Championship Game MVP after recording a double-double of 30 points and 10 rebounds in a 110–98 win over the Portland Trail Blazers in the championship match. On November 3, 2017, in his first game as a starter, he notched his first double-double, with 21 points and 13 rebounds, in a 124–112 win over the Brooklyn Nets. On November 17, he recorded another double-double by scoring 30 points, to go with 10 rebounds, in a 122–113 loss to the Phoenix Suns. Kuzma was named the Western Conference Rookie of the Month for games played in October/November. In 20 games, he averaged a team-high 16.7 points while shooting 50.4 percent overall and a team-leading 37.9 percent on three-point field goals. He was the first ever NBA rookie to compile at least 330 points, 120 rebounds, and 30 made three-pointers in his first 20 games. He was also just the sixth non-lottery pick to win the award in the first month of his career. On December 20, he scored a career-high 38 points on 70% shooting in a 122–116 win over Houston, ending the Rockets' 14-game winning streak. In the following game, he had a team-high 27 points in a 113–106 loss versus the Golden State Warriors to become the first Lakers rookie since Jerry West in 1961 to have scored 25 or more points in three straight games. He played in the Rising Stars Challenge during the 2018 NBA All-Star Weekend, and he was named to the NBA All-RookieFirst Team at the end of the season.
2018–19 season
On October 22, 2018, Kuzma scored a season-high 37 points against the San Antonio Spurs in a 143–142 overtime loss. On January 9, 2019, he scored a career-high 41 points against the Detroit Pistons in a 113–100 win. He was selected again for the Rising Stars game and earned MVP honors after scoring a game-high 35 points.