Thompson was hired by Bell Labs in 1966. In the 1960s at Bell Labs, Thompson and Dennis Ritchie worked on the Multics operating system. While writing Multics, Thompson created the Bonprogramming language. He also created a video game called Space Travel. Later, Bell Labs withdrew from the MULTICS project. In order to go on playing the game, Thompson found an old PDP-7 machine and rewrote Space Travel on it. Eventually, the tools developed by Thompson became the Unix operating system: Working on a PDP-7, a team of Bell Labs researchers led by Thompson and Ritchie, and including Rudd Canaday, developed a hierarchical file system, the concepts of computer processes and device files, a command-line interpreter, pipes for easy inter-process communication, and some small utility programs. In 1970, Brian Kernighan suggested the name "Unix", in a pun on the name "Multics". After initial work on Unix, Thompson decided that Unix needed a system programming language and created B, a precursor to Ritchie's C. In the 1960s, Thompson also began work on regular expressions. Thompson had developed the CTSS version of the editor QED, which included regular expressions for searching text. QED and Thompson's later editor ed contributed greatly to the eventual popularity of regular expressions, and regular expressions became pervasive in Unix text processing programs. Almost all programs that work with regular expressions today use some variant of Thompson's notation. He also invented Thompson's construction algorithm used for converting regular expression into nondeterministic finite automaton in order to make expression matching faster.
1970s
Throughout the 1970s, Thompson and Ritchie collaborated on the Unix operating system; they were so influential on Research Unix that Doug McIlroy later wrote, "The names of Ritchie and Thompson may safely be assumed to be attached to almost everything not otherwise attributed." In a 2011 interview, Thompson stated that the first versions of Unix were written by him, and that Ritchie began to advocate for the system and helped to develop it: Feedback from Thompson's Unix development was also instrumental in the development of the C programming language. Thompson would later say that the C language "grew up with one of the rewritings of the system and, as such, it became perfect for writing systems". In 1975, Thompson took a sabbatical from Bell Labs and went to his alma mater, UC Berkeley. There, he helped to install Version 6 Unix on a PDP-11/70. Unix at Berkeley would later become maintained as its own system, known as the Berkeley Software Distribution. Ken Thompson wrote a chess-playing program called "chess" for the first version of Unix. Later, along with Joseph Condon, Thompson created the hardware-assisted program Belle, a world champion chess computer. He also wrote programs for generating the complete enumeration of chess endings, known as endgame tablebases, for all 4, 5, and 6-piece endings, allowing chess-playing computer programs to make "perfect" moves once a position stored in them is reached. Later, with the help of chess endgame expert John Roycroft, Thompson distributed his first results on CD-ROM. In 2001, the ICGA Journal devoted almost an entire issue to Ken Thompson's various contributions to computer chess.
1980s
Throughout the 1980s, Thompson and Ritchie continued revising Research Unix, which adopted a BSD codebase for the 8th, 9th, and 10th editions. In the mid-1980s, work began at Bell Labs on a new operating system as a replacement for Unix. Thompson was instrumental in the design and implementation of the Plan 9 from Bell Labs, a new operating system utilizing principles of Unix, but applying them more broadly to all major system facilities. Some programs that were part of later versions of Research Unix, such as mk and rc, were also incorporated into Plan 9. Thompson tested early versions of the C++ programming language for Bjarne Stroustrup by writing programs in it, but later refused to work in C++ due to frequent incompatibilities between versions. In a 2009 interview, Thompson expressed a negative view of C++, stating, "It does a lot of things half well and it's just a garbage heap of ideas that are mutually exclusive."
1990s
In 1992, Thompson developed the UTF-8 encoding scheme together with Rob Pike. UTF-8 encoding has since become the dominant character encoding for the World Wide Web, accounting for more than 90% of all web pages in 2019. In the 1990s, work began on the Inferno operating system, another research operating system that was based around a portable virtual machine. Thompson and Ritchie continued their collaboration with Inferno, along with other researchers at Bell Labs.
2000s
In late 2000, Thompson retired from Bell Labs. He worked at Entrisphere, Inc. as a fellow until 2006 and now works at Google as a Distinguished Engineer. Recent work has included the co-design of the Go programming language. Referring to himself along with the other original authors of Go, he states: According to a 2009 interview, Thompson now uses a Linux-based operating system.
In 1983, Thompson and Ritchie jointly received the Turing Award "for their development of generic operating systems theory and specifically for the implementation of the UNIX operating system". His acceptance speech, "Reflections on Trusting Trust", presented the backdoor attack now known as the Thompson hack or trusting trust attack, and is widely considered a seminal computer security work in its own right.
In 1997, both Thompson and Ritchie were inducted as Fellows of the Computer History Museum for "the co-creation of the UNIX operating system, and for development of the C programming language".
On April 27, 1999, Thompson and Ritchie jointly received the 1998 National Medal of Technology from President Bill Clinton for co-inventing the UNIX operating system and the C programming language which together have "led to enormous advances in computer hardware, software, and networking systems and stimulated growth of an entire industry, thereby enhancing American leadership in the Information Age".
In 1999, the Institute of Electrical and Electronics Engineers chose Thompson to receive the first Tsutomu Kanai Award "for his role in creating the UNIX operating system, which for decades has been a key platform for distributed systems work".