Historically, the family was established even before the Principality of Moldova was founded in 1350. They owned the forest on the left bank of the Sereth river, Panka region, Mihondra river valley and founded :uk:Лукавці|Lucavăţ village, which was all owned by Luca, member of the family. The family is said to be, along with the House of Dragoș, the oldest in this region. Luca's sons Stan and Șerbco were knights at the court of PrinceAlexander I of Moldavia. He officially confirmed their family possessions of Lucavăţ, Panka with Mihodra to them with hereditary rights for their descendants by the document of February 16, 1428. The :File:Церква_Святої_Параскеви_з_дзвіницею_в_Луківцях.JPG|church of Lucavăţ became first seat of Bishopric of Rădăuți, with its pastor, by proclamation of Prince Stephen III of Moldavia became its first Bishop on March 15, 1490. Prince Alexandru Lăpușneanu of Moldavia, grandson of Prince Alexander "the Good", not only confirmed the legality of the certificate issued by his grandfather on May 7, 1565, but also subsequently transferred to the family the co-ownership of a large number of villages in northern Moldova which expanded the land they owned. Later, during 17th century, brothers Vasile, Nicolae and Constantin Căzăcescul were again officially confirmed ownership of all their expanded possessions by Prince Illias III of Moldavia on March 12, 1667.
Wassilko von Serecki
Vasile Căzăcescul, the eldest of the above mentioned brothers, married in 1654 Candachia Cocoranul, the daughter of the Boyar Isac Cocoranul. He was, as historian :ro:Teodor Bălan|Teodor Bălan wrote, the ancestor of the Counts :de:Wassilko von Serecki |Wassilko von Serecki.
It was first mentioned as such in the 17th century. Constantin Căzăcescul, younger brother of Vasile and Nicolae, got confirmed in 1667 his noble status and his possessions in the Principality of Moldova by ruling Prince Illias III. His descendants kept using his family name, making him an ancestor of the Keshko family, which in turn made them collateral branch of Counts :File:Grafen_Wassilko_von_Serecki.jpg|Wassilko von Serecki, who were later one of the largest landowners in Austro-Hungarian Empire. It was the only family of ethnic Romanian origin to acquire the title of Count throughout the Empire.
Members of the Keshko family served the Russian Empire. As such they held the title of Marshals of Nobility of the Bessarabia Governorate where they had large properties. Throughout the years they were also incorporated into the Russian nobility, apart from already belonging to :Category:Romanian_noble_families|Romanian and :Category:Moldavian_nobility|Moldavian nobility.
Family tree
Constantin Căzăcescul, whose ancestors used Keșco version of his surname, married Irina Ianni
*Gheorghe Keșco
**Peter Keșco, married Balasa :File:Vârnav_family_coat_of_arms.svg|Vârnav
***Ioanita Keșco, married Tsaritsa Costache , daughter of Manolache Costaki and Princess Ileana Rosetti
****Ioan Keșco,, Russian Marshal of Nobility in Bessarabia, married firstly :Category:Romanian_nobility|Romanian noblewoman Natalia :File:Interbelic_Bals_CoA.png|Balș, daughter of Iordache Balș, Grand treasurer of Moldova and Princess Ruxandra Sturdza, married secondly Zamfira Kalmutki, daughter of Gheorghe Kalmutki
*****Petre Keșco, Colonel in Russian Imperial Army, married his cousin Princess :sr:Pulherija Sturdza|Pulcheria Sturdza of Moldavia
******Maria Keșco, who married on 13 April 1886 Prince Grigor Ghica-Brigadier.
****** Ioana Ecaterina Keșco, who married on 5 February 1883 her relative Prince Eugen Ghica-Comănești.
******Ioniță Keșco, only brother; he was the fourth and last child.
*****Viktoria Keșco, married Bessarabian nobleman of Greek descent Alexander Dimitrievich :File:AIRM_-_Urban_mansion_of_Inglezi_-_1970-ies.jpg|Inglezi, son of :ru:Инглези,_Дмитрий_Спиридонович#Семья|Dimitri Spiridonovich Inglezi