He made his début at St Helens in 2003 and was outstanding as the Bradford Senior Academy took the Championship in 2004. In 2005 he continued his progress and made 21 appearances scoring 17 tries making him third in Bradford's try scoring charts for the year. As Super League champions Bradford faced National Rugby League premiers Wests Tigers in the 2006 World Club Challenge. Pryce played at stand-off half back in the Bulls' 30-10 victory. Pryce was called up to the Great Britain squad in 2006 for the 2006 Tri nations although he did not feature in the competition. Pryce re-fractured a bone in his left foot on his Premiership début in March 2007 and had a pin inserted in his foot. He missed the rest of the season. For the 2007–08 season, Pryce, like other England Academy players at Gloucester, was dual-registered with Moseley, and could play for either club during the season. On 18 December 2007, Wigan announced that they had signed Pryce for the start of the new 2008 Super League Season, although he missed the majority of this season due to an ankle fracture injury, which had also hampered his time at Gloucester. On 10 December, Wigan announced Pryce's début would come in a friendly fixture against Warrington on 28 December. Wigan won 44–4, with Pryce scoring two tries. Pryce made his return to Super League on 20 February against Castleford. Despite Castleford winning the game 22–28 Karl Pryce scored a single try. Pryce featured in the Challenge cup 4th round tie against Barrow scoring a try. Pryce has played the majority of the season in Wigan's Reserve team. He made 14 appearances scoring 20 tries and has played in the centres, wing and stand off.
2010s
In 2012 Mick Potter signed Pryce on a 1-year deal for the 2012 season. The 25-year-old can play Wing, Centre and Second Row. Pryce did not feature in any of the pre-season games because of a hamstring injury. Karl missed Rounds 1–4 due to an injury. He featured in five consecutive games from Round 6 to Round 10. Pryce returned in Round 12 to Round 23. Pryce also played in Round 25 and Round 26. He was injured for Round 11, 27 and Round 4 of the Challenge Cup. He also featured against Warrington in the Challenge Cup. Pryce scored against Hull Kingston Rovers, St. Helens, Hull F.C., London Broncos, Salford, Wigan, Leeds, Warrington and Huddersfield. He was released at the end of the season.
