He made his debut for the Rangers on September 26, 2004, against the Seattle Mariners, working 2.2 scoreless innings of relief. In his next appearance on September 29, he made his first start against the Anaheim Angels. He allowed five runs in 4 innings but did not receive a decision. He recorded his first win in a two inning extra-inning relief appearance against the Angels on June 29, 2005. In the 2005 season, Loe made 48 appearances, 8 of them starts, compiling a record of 9–6, with a 3.42 ERA. Loe missed much of the due to a bone bruise in his right elbow. In late March 2008 he was considered one of three pitchers vying for one long relief spot with the team, along with Josh Rupe and Scott Feldman. From 2004-2008 with the Rangers, he pitched in 107 games with a 4.77 ERA.
On November 20, 2008, Loe was acquired by the Fukuoka SoftBank Hawks. He appeared in just 5 games for the Hawks and was 0-4 with a 6.33 ERA.
Milwaukee Brewers
On December 18, 2009, Loe signed a minor league contract with the Milwaukee Brewers, that contained an invite to spring training. After beginning the season with the AAA Nashville Sounds, Loe was called up to the big league roster by the Brewers on June 1, 2010. In 2011, he was 4-7 with a 3.50 ERA. In 2012, Loe went 6-5 with a 4.61 ERA with 68.1 innings in 70 appearances. On November 2, Loe elected to become a free agent after refusing his minor league assignment. In parts of 3 seasons with the Brewers, he was 13-17 with a 3.67 ERA in 195 games.
After being released by the Mariners, Loe signed a minor league contract with the Chicago Cubs. Following many relief pitching appearances, he was released on May 10, 2013.
Atlanta Braves
On May 11, 2013 Loe signed a minor league contract with the Atlanta Braves. After pitching in 21 games for Triple-A Gwinnett, he was called up on July 21. On July 29, Loe was designated for assignment to make room for the recently acquired Scott Downs. Loe pitched in 2 games for Atlanta, giving up 3 runs in 2.2 innings. Loe did not make the Braves' postseason roster,
Loe signed a minor league deal with the San Francisco Giants on January 13, 2014. On March 22, 2014, Loe opted out of his contract and became a free agent.
Loe signed a minor league deal with the Arizona Diamondbacks on July 5, 2014. After becoming a free agent following the season, Loe tested positive for a "drug of abuse" and was suspended for 50 games.
Married Bree Ransom of Scottsdale, AZ and they have a child by the name of Brynlee Loe who was born in 2016. Loe owned a 7-foot boa constrictor named Angel who he put up for adoption when he left the United States and moved to Japan for his job with the Fukuoka SoftBank Hawks in 2009.
